The effect of monascin on hematoma clearance and edema after intracerebral hemorrhage in rats
| Autor: | Liang Dong, Gaiqing Wang, Yi Xu, Juan Wang, Tong Li, Shu-na Duan, Jinying Yi, Xin-gang Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine NF-E2-Related Factor 2 Brain Edema Hemoglobin levels Blood–brain barrier Neuroprotection Capillary Permeability Rats Sprague-Dawley Random Allocation 03 medical and health sciences 0302 clinical medicine Hematoma Edema medicine Animals cardiovascular diseases Cerebral Hemorrhage Intracerebral hemorrhage Dose-Response Relationship Drug medicine.diagnostic_test business.industry General Neuroscience Magnetic resonance imaging medicine.disease PPAR gamma Disease Models Animal Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure High dosage Blood-Brain Barrier Anesthesia cardiovascular system medicine.symptom business Heterocyclic Compounds 3-Ring 030217 neurology & neurosurgery |
| Zdroj: | Brain Research Bulletin. 134:24-29 |
| ISSN: | 0361-9230 |
| Popis: | Background and purpose Intracerebral hemorrhage (ICH) is a particularly devastating form of stroke with high mortality and morbidity. Hematomas are the primary cause of neurologic deficits associated with ICH. The products of hematoma are recognized as neurotoxins and the main contributors to edema formation and tissue damage after ICH. Finding a means to efficiently promote absorption of hematoma is a novel clinical challenge for ICH. Peroxisome proliferator-activated receptor gamma (PPARγ) and nuclear factor erythroid 2-related factor 2 (Nrf2), had been shown that, can take potential roles in the endogenous hematoma clearance. However, monascin, a novel natural Nrf2 activator with PPARγ agonist, has not been reported to play a role in ICH. This study was designed to evaluate the effect of monascin on neurological deficits, hematoma clearance and edema extinction in a model of ICH in rats. Methods 164 adult male Sprague-Dawley (SD) rats were randomly divided into sham; vehicle; monascin groups with low dosages (1 mg/kg/day), middle dosages (5 mg/kg/day) and high dosages (10 mg/kg/day) respectively. Animals were euthanized at 1, 3 and 7 days following neurological evaluation after surgery. We examined the effect of monascin on the brain water contents, blood brain barrier (BBB) permeability and hemoglobin levels, meanwhile reassessed the volume of hematoma and edema around the hematoma by Magnetic Resonance Imaging (MRI) in each group. Results The high dosage of monascin significantly improved neurological deficits, reduced the volume of hematoma in 1–7 days after ICH, decreased BBB permeability and edema formation in 1–3 days following ICH. Conclusion Our study demonstrated that the high dosage of monascin played a neuroprotective role in ICH through reducing BBB permeability, edema and hematoma volume. |
| Databáze: | OpenAIRE |
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