Recruitment maneuver: RAMP versus CPAP pressure profile in a model of acute lung injury
| Autor: | Viviane Ramos Cagido, Walter A. Zin, Sabrina V. Martini, Cristiane S.N. Baez-Garcia, Patricia R. M. Rocco, Débora S. Faffe, D. R. Riva, Marcelo M. Morales, Renata S. Contador, Debora G. Xisto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Paraquat
Recruitment Neurophysiological Pulmonary and Respiratory Medicine Physiology medicine.medical_treatment Acute Lung Injury Lung injury Positive-Pressure Respiration medicine Animals RNA Messenger Continuous positive airway pressure Rats Wistar Respiratory system Lung Saline Analysis of Variance business.industry General Neuroscience Respiratory disease respiratory system medicine.disease Rats respiratory tract diseases Disease Models Animal Collagen Type III medicine.anatomical_structure Gene Expression Regulation Anesthesia Respiratory Mechanics Lung Volume Measurements business Airway circulatory and respiratory physiology Transpulmonary pressure |
| Zdroj: | Respiratory Physiology & Neurobiology. 169:62-68 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2009.08.010 |
| Popis: | We examined whether recruitment maneuvers (RMs) with gradual increase in airway pressure (RAMP) provide better outcome than continuous positive airway pressure (CPAP) in paraquat-induced acute lung injury (ALI). Wistar rats received saline intraperitoneally (0.5 mL, CTRL) or paraquat (15 mg/kg, ALI). Twenty-four hours later lung mechanics [static elastance, viscoelastic component of elastance, resistive, viscoelastic and total pressures] were determined before and after recruitment with 40 cmH2O CPAP for 40 s or 40-s-long slow increase in pressure up to 40 cmH2O (RAMP) followed by 0 or 5 cmH2O PEEP. Fractional area of alveolar collapse and PCIII mRNA were determined. All mechanical parameters and the fraction area of alveolar collapse were higher in ALI compared to CTRL. Only RAMP-PEEP maneuver significantly improved lung mechanics and decreased PCIII mRNA expression (53%) compared with ALI, while both RMs followed by PEEP decreased alveolar collapse. In conclusion, in the present experimental ALI model, RAMP followed by 5 cm H2O PEEP yields a better outcome. |
| Databáze: | OpenAIRE |
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