HLA-A, -B, -DRB1 and -DQB1 polymorphisms among Iraqi Arabs
| Autor: | Aaiad H. Al-rikabi, Ali H. Ad'hiah, Liath A. Kamil, Zahra’a Abdul-Raheem Ahmed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine Adolescent endocrine system diseases Immunology Population Human leukocyte antigen Biology Young Adult 03 medical and health sciences 0302 clinical medicine Gene Frequency immune system diseases Polymorphism (computer science) HLA-DQ beta-Chains Humans Immunology and Allergy Allele skin and connective tissue diseases education Allele frequency Alleles Genetics education.field_of_study Polymorphism Genetic HLA-A Antigens Histocompatibility Testing Haplotype General Medicine Middle Aged Tissue Donors Arabs Genotype frequency HLA-A 030104 developmental biology Haplotypes HLA-B Antigens Iraq Female HLA-DRB1 Chains 030215 immunology |
| Zdroj: | Human Immunology. 81:191-192 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2020.03.006 |
| Popis: | In this report, HLA polymorphisms (A, B, DRB1 and DQB1 loci) were determined in 149 unrelated Iraqi Arab potential bone marrow and kidney donors. Molecular genotyping was carried out by polymerase chain reaction followed by specific oligonucleotide probe hybridizations. Data were analyzed by Arlequin software. HLA-A, -B and -DRB1 genotype frequencies were significantly deviated from Hardy-Weinberg equilibrium, while HLA-DQB1 frequencies showed no deviation. A*03, B*35, DRB1*11 and DQB1*02 were the most frequent allele groups, while A*02-B*07-DRB1*04-DQB1*03 was the most frequent haplotype. HLA data are available in the Allele Frequencies Net Database (AFND: 3680) under the population name "Iraq Arabs". |
| Databáze: | OpenAIRE |
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