Inhibitory effect of the cannabinoid receptor agonist WIN 55,212-2 on pentagastrin-induced gastric acid secretion in the anaesthetized rat
| Autor: | G Coppelli, Gabriella Coruzzi, Giulio Soldani, Paolo Frati, Maristella Adami |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Agonist medicine.medical_specialty Indoles Cannabinoid receptor medicine.drug_class Morpholines Receptors Drug medicine.medical_treatment Naphthalenes Gastric Acid Receptor Cannabinoid CB2 Isomerism Piperidines Internal medicine medicine Cannabinoid receptor type 2 Animals Anesthesia Rats Wistar Receptors Cannabinoid Receptor WIN 55 212-2 Pharmacology Camphanes Cannabinoids Chemistry General Medicine Benzoxazines Rats Pentagastrin Endocrinology Gastric Mucosa Pyrazoles Gastric acid lipids (amino acids peptides and proteins) Cannabinoid Rimonabant medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 360:715-718 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/s002109900135 |
| Popis: | The effect of the cannabinoid (CB) receptor agonist WIN 55,212-2 on gastric acid secretion was studied in the anaesthetized rat after stimulation with pentagastrin. WIN 55,212-2 (0.5-2 mg/kg, i.v.) was inactive on basal secretion but caused a marked inhibition (80%) of the acid secretion stimulated by pentagastrin (10 microg/kg, i.v.). The enantiomer WIN 55,212-3 (1-3 mg/kg, i.v.) did not significantly modify basal or pentagastrin-induced acid secretion. The inhibitory effect of WIN 55,212-2 against pentagastrin was prevented by the administration of the selective cannabinoid CB1 receptor antagonists SR141716A (1 mg/kg, i.v.) and LY320135 (1 mg/kg, i.v.); by contrast, the CB2 receptor antagonist SR144528 (0.3-1 mg/kg, i.v.) was without effect. The selective CB2 receptor agonist JWH-015 (0.1-10 mg/kg, i.v.) was inactive on the increase of acid output stimulated by pentagastrin. These results suggest that the inhibitory effect of WIN 55,212-2 on pentagastrin-stimulated acid secretion in the anaesthetized rat is mediated by specific cannabinoid receptors. Moreover, the antagonism of WIN 55,212-2-induced effects by the selective CB1 receptor antagonists SR141716A and LY320135 together with the ineffectiveness of both the CB2 receptor agonist JWH-015 and the CB2 receptor antagonist SR144528 indicate that CB1 receptor subtypes are predominantly involved in the antisecretory effect of WIN 55,212-2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink