Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer
| Autor: | Morshed Alam, Chi Lin, Michael J. Baine, Jeffrey M. Ryckman, Lynnette Smith, Mark F. McLaughlin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Lung Neoplasms medicine.medical_treatment Cancer Treatment Kaplan-Meier Estimate Lung and Intrathoracic Tumors White Blood Cells 0302 clinical medicine Cancer immunotherapy Animal Cells Carcinoma Non-Small-Cell Lung Medicine and Health Sciences Lymphocytes Stage (cooking) Multidisciplinary Incidence hemic and immune systems Middle Aged 030220 oncology & carcinogenesis Cohort Disease Progression Medicine Female Immunotherapy Cellular Types Research Article Clinical Oncology medicine.medical_specialty Science Immune Cells Immunology Radiation Therapy chemical and pharmacologic phenomena Radiosurgery Cancer Immunotherapy Disease-Free Survival Pancreatic Cancer 03 medical and health sciences Signs and Symptoms Lymphopenia Internal medicine Pancreatic cancer Gastrointestinal Tumors parasitic diseases medicine Humans Progression-free survival Radiation Injuries Lung cancer Aged Neoplasm Staging Chemotherapy Blood Cells business.industry Biology and Life Sciences Cancers and Neoplasms Cell Biology medicine.disease biological factors Non-Small Cell Lung Cancer Radiation therapy 030104 developmental biology Clinical Immunology Clinical Medicine business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 11, p e0241505 (2020) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0241505 |
| Popis: | Introduction Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been examined in other sites commonly treated with SBRT. This work examines if SBRT similarly spares RIL in patients with non-small cell lung cancer (NSCLC). Materials and methods Retrospective analysis was done at a single institution on 40 distinct cases of SBRT for early stage NSCLC from 2006–2017. Incidentally collected lymphocyte counts collected within 6 months of SBRT treatment were analyzed to determine if RIL occurred. The presence of RIL was correlated with location of initial failure and survival endpoints. Kaplan-Meier curves were constructed with significance defined at the level p < 0.05. Results RIL was observed in 35% of the analyzed patients. Patterns of failure and survival data were comparable to prior SBRT literature. There was no observed association in two year local, nodal, or distant failure, progression free survival, or overall survival based on the presence of RIL. Discussion SBRT spares RIL in NSCLC compared to historical rates observed with conventionally fractionated radiation. As understanding of the role of the immune system in cancer control continues to evolve, the importance of RIL sparing techniques take on increasing importance. This study represents further analysis of RIL sparing in SBRT in an early stage NSCLC cohort without the confounding influence of chemotherapy. |
| Databáze: | OpenAIRE |
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