Colokinetic effect of somatostatin in the spinal defecation center in rats
Autor: | Takahiko Shiina, Yuuki Sano, Hiroki Shimaoka, Yasutake Shimizu, Kiyotada Naitou, Hiroyuki Nakamori |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine endocrine system medicine.medical_specialty Cord Colon Physiology Motility Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Large intestine Defecation Injections Spinal business.industry Spinal cord Rats Autonomic nervous system 030104 developmental biology medicine.anatomical_structure Somatostatin Endocrinology Nociception Spinal Cord Gastrointestinal Motility business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
Zdroj: | The Journal of Physiological Sciences. 68:243-251 |
ISSN: | 1880-6562 1880-6546 |
Popis: | Somatostatin and its receptors are expressed in the spinal cord, but the functional roles of the peptide remain unknown. In this study, we examined the colokinetic effect of somatostatin in the spinal defecation center in anesthetized rats. Intrathecal application of somatostatin into the lumbo-sacral cord caused propulsive contractions of the colorectum. However, somatostatin administered intravenously or intrathecally to the thoracic cord failed to enhance colorectal motility. Transection of the thoracic cord had no significant impact on the colokinetic action of somatostatin. The enhancement of colorectal motility by intrathecal administration of somatostatin was abolished by severing the pelvic nerves. Our results demonstrate that somatostatin acting on the spinal defecation center causes propulsive motility of the colorectum in rats. Considering that somatostatin is involved in nociceptive signal transmission in the spinal cord, our results provide a rational explanation for the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients. |
Databáze: | OpenAIRE |
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