Chemoreduction for retinoblastoma. Analysis of tumor control and risks for recurrence in 457 tumors
| Autor: | Jacqueline Cater, Carol L. Shields, Jerry A. Shields, Arman Mashayekhi, Anna T. Meadows, Abdallah Shelil |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Vincristine Adolescent Retinal Neoplasms medicine.medical_treatment Eye disease Cryotherapy Single Center Risk Assessment Eye Enucleation Carboplatin chemistry.chemical_compound Risk Factors Antineoplastic Combined Chemotherapy Protocols Humans Medicine Prospective Studies Child Prospective cohort study Etoposide business.industry Retinoblastoma Infant Hyperthermia Induced medicine.disease Combined Modality Therapy Surgery Ophthalmology 2004 Papers chemistry Child Preschool Multivariate Analysis Female Neoplasm Recurrence Local business Nuclear medicine medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 138:329-337 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To evaluate retinoblastoma control following chemoreduction. Design Interventional case series. Methods Prospective. Setting Single center trial. Patient population 457 retinoblastomas in 193 eyes of 125 patients. Nonrandomized, noncomparative study. Intervention All patients received intravenous vincristine, etoposide, and carboplatin,. The tumors were managed with chemoreduction alone (group W) or chemoreduction combined with thermotherapy (group X), cryotherapy (group Y), or both thermotherapy and cryotherapy (group Z). Main outcome measure Tumor recurrence in each treatment group. Results Of 457 retinoblastomas, 63 (14%) were in group W, 256 (56%) in group X, 127 (28%) in group Y, and 11 (2%) in group Z. The tumor was located in the macula in 33 (52%) of group W, 109 (43%) of group X, 3 (2%) of group Y, and 9 (1%) of group Z. The mean tumor thickness at initial examination was 7 mm for group W, 4 mm for group X, 2 mm for group Y, and 3 mm for group Z. Using Kaplan-Meier estimates, recur-rence of the individual retinoblastoma at 7 years was found in 45% of group W and 18% for combined groups X, Y, and Z. Risk factors predictive of tumor recurrence by multivariate analysis included macular tumor location for all groups and additionally female gender for group W and increasing tumor thickness for groups X, Y, and Z. Conclusions Chemoreduction alone or combined with cryotherapy or thermotherapy is effective for treatment of retinoblastoma, but tumor recurrence rate is highest for those located in the macula and those with greater thickness. |
| Databáze: | OpenAIRE |
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