Review of Theoretical Models to Study Natural Products with Antiprotozoal Activity
| Autor: | Miguel Ángel Herrera-Rueda, Jorge Vergara-Galicia, Francisco J. Prado-Prado, Francisco Aguirre-Crespo, Xerardo García-Mera, María Guadalupe Maldonado-Velázquez, Hilario Chi Canul, Gabriel Navarrete-Vázquez |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Models Molecular Quantitative structure–activity relationship medicine.drug_class Antiparasitic media_common.quotation_subject Clinical Biochemistry Theoretical models Antiprotozoal Agents Quantitative Structure-Activity Relationship Computational biology Biology Pharmacology 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences 0302 clinical medicine Single species Drug Discovery medicine Humans Computer Simulation 0101 mathematics media_common Biological Products Antiparasitic Drugs Computational Biology 010101 applied mathematics Antiprotozoal Molecular Medicine Drug receptor |
| Zdroj: | Current drug targets. 18(5) |
| ISSN: | 1873-5592 |
| Popis: | In nature, pathogenic parasite species with different susceptibility patterns of antiparasitic drugs abound. In this sense, natural products derived from plants are a potency for drugs with potential antiparasitic activity. Unfortunately, there are many metabolites and studying all of them would be costly in terms of money and resources. To this end, theoretical studies such as QSAR models could be useful. These, for the most part, predict the biological activity of the drugs against a single species of parasite. Consequently, foretell the probability with which a drug is active against many different species with a single QSAR model is an important achievement. This review consists of three parts: the first part is a review of metabolites found in nature that have antiparasitic activity, in particular the antiprotozoal (Leishmania and Trypanosoma); the second part includes a review of theoretical studies looking for a model that predicts the antiprotozoal activity of natural products; the third and final part concerns the study of theoretical models focused on the interaction between drug and receptor, analyzing new metabolites with antiprotozoal activity. |
| Databáze: | OpenAIRE |
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