Several pathways of hydrogen peroxide action that damage the E. coli genome
Autor: | Israel Felzenszwalb, L.M.B.O Asad, Alvaro C. Leitão, Carlos Eduardo Bonacossa de Almeida, Januário B. Cabral-Neto, Nasser R Asad |
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Rok vydání: | 2004 |
Předmět: |
chemistry.chemical_classification
Reactive oxygen species lcsh:QH426-470 DNA repair Mutagenesis cross-adaptive response hydrogen peroxide Base excision repair Biology medicine.disease_cause lcsh:Genetics chemistry.chemical_compound chemistry Biochemistry Genetics medicine copper and iron Hydrogen peroxide Molecular Biology Escherichia coli Oxidative stress lethal synergism Nucleotide excision repair |
Zdroj: | Genetics and Molecular Biology, Vol 27, Iss 2, Pp 291-303 (2004) Genetics and Molecular Biology, Volume: 27, Issue: 2, Pages: 291-303, Published: 2004 Genetics and Molecular Biology v.27 n.2 2004 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG |
ISSN: | 1415-4757 |
Popis: | Hydrogen peroxide is an important reactive oxygen species (ROS) that arises either during the aerobic respiration process or as a by-product of water radiolysis after exposure to ionizing radiation. The reaction of hydrogen peroxide with transition metals imposes on cells an oxidative stress condition that can result in damage to cell components such as proteins, lipids and principally to DNA, leading to mutagenesis and cell death. Escherichia coli cells are able to deal with these adverse events via DNA repair mechanisms, which enable them to recover their genome integrity. These include base excision repair (BER), nucleotide excision repair (NER) and recombinational repair. Other important defense mechanisms present in Escherichia coli are OxyR and SosRS anti-oxidant inducible pathways, which are elicited by cells to avoid the introduction of oxidative lesions by hydrogen peroxide. This review summarizes the phenomena of lethal synergism between UV irradiation (254 nm) and H2O2, the cross-adaptive response between different classes of genotoxic agents and hydrogen peroxide, and the role of copper ions in the lethal response to H2O2 under low-iron conditions. |
Databáze: | OpenAIRE |
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