Preparation and Characterization of Ion-Irradiated Nanodiamonds as Photoacoustic Contrast Agents
| Autor: | Cheng-Chun Chang, Chia-Yi Fang, Huan-Cheng Chang, Chung-Yuan Mou |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Diagnostic Imaging
Materials science Cell Survival Biomedical Engineering Analytical chemistry Contrast Media Bioengineering engineering.material Sensitivity and Specificity Nanodiamonds Nanomaterials Ion Photoacoustic Techniques Materials Testing Humans Heavy Ions General Materials Science Thermal stability Irradiation Reproducibility of Results Diamond General Chemistry Molar absorptivity Condensed Matter Physics engineering Particle Nanorod HeLa Cells |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 15:1037-1044 |
| ISSN: | 1533-4899 1533-4880 |
| Popis: | Highly radiation-damaged or irradiated nanodiamonds (INDs) are a new type of nanomaterial developed recently as a potential photoacoustic (PA) contrast agent for deep-tissue imaging. This work characterized in detail the photophysical properties of these materials prepared by ion irradiation of natural diamond powders using various spectroscopic methods. For 40-nm NDs irradiated with 40-keV He+ at a dose of 3 x 10(15) ions/cm2, an average molar extinction coefficient of 4.2 M-1 cm-1 per carbon atom was measured at 1064 nm. Compared with gold nanorods of similar dimensions (10 nm x 67 nm), the INDs have a substantially smaller (by > 4 orders of magnitude) molar extinction coefficient per particle. However, the deficit is readily compensated by the much higher thermal stability, stronger hydrophilic interaction with water, and a lower nanobubble formation threshold (~30 mJ/cm2) of the sp3-carbon-based nanomaterial. No sign of photodamage was detected after high-energy (>100 mJ/cm2) illumination of the INDs for hours. Cell viability assays at the IND concentration of up to 100 µg/mL showed that the nanomaterial is non-cytotoxic and potentially useful for long-term PA bioimaging applications. |
| Databáze: | OpenAIRE |
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