Electrohydrodynamic methods for the development of pulmonary drug delivery systems
| Autor: | Nikolaou, Maria, Krasia-Christoforou, Theodora |
|---|---|
| Přispěvatelé: | Krasia-Christoforou, T. [0000-0002-9915-491X], Krasia-Christoforou, Theodora [0000-0002-9915-491X] |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers Chemistry Pharmaceutical Pharmaceutical Science Nanotechnology 02 engineering and technology investigative procedures 010402 general chemistry 01 natural sciences Article Drug Delivery Systems Inhalation medicine Nano Administration Inhalation Humans drug delivery system human Electrospraying Lung Electrospinning nanoparticle Dry Powder Inhalers Electrochemical Techniques 021001 nanoscience & nanotechnology Pulmonary drug delivery 0104 chemical sciences Nanostructures Drug Liberation Respiratory Tract Absorption priority journal Drug delivery hydrodynamics Hydrodynamics Electrohydrodynamics Powders 0210 nano-technology electrohydrodynamics |
| Zdroj: | European Journal of Pharmaceutical Sciences European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences Eur J Pharm Sci |
| Popis: | Electrospinning and electrospraying are two highly versatile and scalable electrohydrodynamic methods, which have attracted considerable attention during the last years towards the fabrication of polymer-based drug delivery systems. The latter may be obtained in the form of nano- or microfibers (via electrospinning) or as drug-loaded nano- and microparticles (via electrospraying). This review article begins with an introduction on the basic principles and the important influencing parameters governing the electrospinning/electrospraying processes, followed by an overview on their use for the development of nano/microfibers and nano/microparticles destined for use in pharmaceutical applications. Focus is given on research efforts targeting in the formulation of drug delivery systems and devices designed for pulmonary drug delivery applications thus emphasizing on the potential use of electrospinning and electrospraying in the area of inhaled medicines. © 2017 Elsevier B.V. 113 29 40 29-40 |
| Databáze: | OpenAIRE |
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