The effect of oxidative stress on the progression of Hashimoto’s thyroiditis

Autor: Dilek Berker, Mustafa Altay, Fatma Yılmaz, Nisbet Yilmaz, Mehmet Fettah Arikan, Ihsan Ates, Serdar Güler
Rok vydání: 2017
Předmět:
Adult
Male
endocrine system
medicine.medical_specialty
Turkey
endocrine system diseases
Physiology
Thyroid Gland
Thyrotropin
030209 endocrinology & metabolism
Hashimoto Disease
030204 cardiovascular system & hematology
medicine.disease_cause
Sensitivity and Specificity
Gastroenterology
Thyroiditis
Autoimmune thyroiditis
03 medical and health sciences
0302 clinical medicine
Risk Factors
Physiology (medical)
Internal medicine
medicine
Humans
Euthyroid
Prospective Studies
Proportional Hazards Models
Subclinical infection
Asymptomatic Diseases
business.industry
Thyroid
General Medicine
Middle Aged
medicine.disease
Oxidative Stress
Thyroxine
medicine.anatomical_structure
Disease Progression
Female
business
Algorithms
Biomarkers
hormones
hormone substitutes
and hormone antagonists
Oxidative stress
Follow-Up Studies
Zdroj: Archives of Physiology and Biochemistry. 124:351-356
ISSN: 1744-4160
1381-3455
DOI: 10.1080/13813455.2017.1408660
Popis: We aimed to investigate the effects of oxidative stress in the pathogenesis and progression of Hashimoto's thyroiditis (HT).Forty euthyroid and 40 subclinical hypothyroid patients older than 18 years and not yet had received treatment were enrolled in the study.In the 9 months follow-up, 14 of the HT patients developed overt hypothyroidism. The mean total oxidant status (TOS) and oxidative stress index (OSI) were higher in patients who developed overt hypothyroidism than those who did not (p .001). And no significant difference was found between the two groups in terms of paraoxanase-1 and arylesterase (p .05). Multivariable Cox regression model showed thyroid stimulating hormone level (HR = 1.348, p .001), free-thyroxine level (HR = 0.481, p = .017) and OSI ratio (HR = 2.349, p .001) to be independent predictors of development of overt hypothyroidism. OSI level, being over 2.96 with 92.9% sensitivity and 62.5% specificity, predicts the risk of hypothyroidism.Oxidative stress may be an effective risk factor in the development of overt hypothyroidism in HT.
Databáze: OpenAIRE
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