Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium

Autor:	Derek R. Case, Robert P. Doyle, Ren Gonzalez, Jon Zubieta
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Glycylglycine education.field_of_study Magnesium General Chemical Engineering Population chemistry.chemical_element General Chemistry Magnesium deficiency (plants) Article chemistry.chemical_compound Chemistry chemistry Chelation education QD1-999 Nuclear chemistry
Zdroj:	ACS Omega ACS Omega, Vol 6, Iss 49, Pp 33454-33461 (2021)
ISSN:	2470-1343
Popis:	Human chronic latent magnesium deficiency is estimated to impact a substantive portion of the world’s population. A number of magnesium compounds have been developed to combat this deficiency; however, none are ideal due to issues of solubility, absorption, side effects (e.g., laxation) and/or formulation. Here, we describe the pH-dependent synthesis, chemical characterization (inductively coupled plasma and thermal analysis, infrared and nuclear magnetic resonance (1D and 2D) spectroscopies, and electrospray mass spectrometry) and in vitro uptake (in a cell model of the large intestine (CaCo-2 cells)) of a magnesium complex of the glycine dimer (HG2). Results demonstrate that the HG2 ligand assumes a tridentate coordination mode with an N2O donor set and an octahedral coordination sphere completed with coordinated waters. The magnesium:HG2 complex exhibits significant solubility and cellular uptake.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f178a0a4e9e25327b2cd81e86c9e4dd http://europepmc.org/articles/PMC8679001 Zobrazit plný text záznamu