Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies
| Autor: | A.D. Heemskerk, Ben J. Marais, James A Seddon, Helen McIlleron, Anthony Figaji, Guy E. Thwaites, Nguyen Th Mai, Usha K. Misra, Robert J. Wilkinson, Suzaan Marais, Rob E. Aarnoutse, R Van Toorn, Graeme Meintjes, Maxine Caws, Ursula K. Rohlwink, Johan F. Schoeman, Rovina Ruslami, Regan Solomons, R. van Crevel |
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| Přispěvatelé: | Wellcome Trust |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Standardization 030106 microbiology urologic and male genital diseases Microbiology core dataset Tuberculous meningitis 03 medical and health sciences research methods wl_200 qv_771 medicine wx_150 Generalizability theory Intensive care medicine Cause of death Data collection business.industry 11 Medical And Health Sciences 06 Biological Sciences Medical research medicine.disease 3. Good health Surgery Viewpoints lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Infectious Diseases Clinical research clinical research tuberculous meningitis Observational study wf_200 business |
| Zdroj: | Clinical Infectious Diseases, 64, 501-509 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America Clinical Infectious Diseases, 64, 4, pp. 501-509 |
| ISSN: | 1058-4838 1537-6591 |
| DOI: | 10.1093/cid/ciw757 |
| Popis: | Summary This viewpoint defines a tuberculous meningitis core dataset, including demographic and clinical information, key patient management and monitoring data, and standardized reporting of patient outcomes. Wide adoption of standardized methods will provide a robust evidence base to improve patient outcomes. Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of TBM clinical research that were drafted at an international tuberculous meningitis research meeting organized by the Oxford University Clinical Research Unit in Vietnam. We propose a core dataset including demographic and clinical information to be collected at study enrollment, important aspects related to patient management and monitoring, and standardized reporting of patient outcomes. The criteria proposed for the conduct of observational and intervention TBM studies should improve the quality of future research outputs, can facilitate multicenter studies and meta-analyses of pooled data, and could provide the foundation for a global TBM data repository. |
| Databáze: | OpenAIRE |
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