Curcumin Prevents Cyclophosphamide-Induced Lung Injury in Rats by Suppressing Oxidative Stress and Apoptosis
| Autor: | Ayman M. Mahmoud, Mahfoudh A. M. Abdulghani, Medhat Taha, Naif A. Al-Gabri, May Bin-Jumah, Hagar Y. Rady, Amir M. Al Hroob, Nouran K. Olama, Sulaiman A. Alharbi, Amer A. Almaiman, Maged A. Al-Garadi, Sultan A M Saghir |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
antioxidant Bioengineering Lung injury Pharmacology lcsh:Chemical technology medicine.disease_cause lcsh:Chemistry Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edema medicine Chemical Engineering (miscellaneous) lcsh:TP1-1185 curcumin pulmonary injury protein carbonyl chemistry.chemical_classification biology Chemistry Process Chemistry and Technology Glutathione peroxidase apoptosis Malondialdehyde 030104 developmental biology lcsh:QD1-999 Apoptosis 030220 oncology & carcinogenesis biology.protein Curcumin cyclophosphamide medicine.symptom Oxidative stress |
| Zdroj: | Processes Volume 8 Issue 2 Processes, Vol 8, Iss 2, p 127 (2020) |
| ISSN: | 2227-9717 |
| DOI: | 10.3390/pr8020127 |
| Popis: | Curcumin (CUR) has been used since ancient times to treat several ailments as it possesses many pharmacological activities. This study intended to explore the mechanism underlying the protective effects of CUR in remodeling oxidative stress and apoptotic signals in cyclophosphamide (CP)-induced pulmonary injury in albino rats. CUR was administered at a dose of 300 mg/kg/day for 7 days and on the seventh day a single dose of CP (200 mg/kg) was given. Histopathological and ultrastructural examinations of CP-intoxicated rats showed complete alveolar obstruction, thickened inter-alveolar septa, enlarged blood vessels, severe inflammatory edema with pyknotic nuclei, and disappearance of cytoplasmic organelles. Significant increases in caspase-3, malondialdehyde (MDA), and protein carbonyl (PCO) and significant decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) were observed. In contrast, rats that received CUR showed clear and empty lumina with single row of pneumocytes, disappearance of edema, and no interstitial electron dense bodies in rats&rsquo lung tissues. Additionally, CUR significantly reduced caspase-3, MDA, and PCO and increased SOD and GPx. In conclusion, these findings revealed the protective effects of CUR against CP-induced pulmonary injury in rats through suppressing oxidative damage and apoptosis. |
| Databáze: | OpenAIRE |
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