Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers
| Autor: | Marie Claude Costes-Salon, Paolo Pizzinelli, Pierre Philip, Stéphane Béroud, Daniela Lucini, Massimo Pagani, Cinzia Ferreri, Olivier Blin, Anne Pavy-Le Traon, Silvia Beltrami, Marie Pierre Bareille |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Polysomnography Hemodynamics Blood Pressure Baroreflex Autonomic Nervous System Cellular and Molecular Neuroscience Heart Rate Heart rate Humans Medicine Autonomic dysregulation Wakefulness Endocrine and Autonomic Systems business.industry Middle Aged Sleep in non-human animals Sleep deprivation Autonomic nervous system Blood pressure Anesthesia Sleep Deprivation Female Neurology (clinical) medicine.symptom business Stress Psychological |
| Zdroj: | Autonomic Neuroscience. 145:76-80 |
| ISSN: | 1566-0702 |
| DOI: | 10.1016/j.autneu.2008.10.009 |
| Popis: | Sleep disorders are associated to a number of cardiovascular disturbances that might increase cardiovascular risk. Sleep deprivation, in particular, might, by inducing autonomic dysregulation, raise arterial pressure and hypertensive risk. Available evidence however is contradictory.We tested the main hypothesis that one night sleep deprivation in 24 volunteers might alter hemodynamics (heart rate and Arterial Pressure - AP), autonomic regulation (mono and bivariate spectral analysis of RR and non invasive AP variability) and baroreflex control (spectral index alpha and spontaneous baroreflex slope), performance indices (reaction time) and subjective stress (questionnaires and salivary cortisol). Volunteers were studied in normal living conditions and while kept in isolation and confinement, to test the presence of possible bias related to environmental stress.Results indicate that there were no differences between normal living conditions and isolation and confinement (Intraclass Correlation Coefficient0.75 for most variables). Conversely, after one night sleep deprivation subjects felt tired (p0.05), and performance deteriorated (p0.05), while cortisol profile was substantially maintained, hemodynamic parameters did not change and HRV and index alpha increased slightly.Findings support the contention that one night sleep deprivation, in absence of significant additional stress or disturbances, does not lead to increased arterial pressure values or to changes in autonomic or baroreflex profiles that could conceivably favor hypertension development, but induces the expected increase in tiredness and reduction in performance. |
| Databáze: | OpenAIRE |
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