The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers
| Autor: | Dianne J. Marais, Gita Ramjee, Anna-Lise Williamson, Bruce Allan, Henri Carrara, Patti Kay |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
medicine.medical_specialty Nonoxynol Uterine Cervical Neoplasms Cervix Uteri Biology Spermatocidal Agents Placebo Virus Cohort Studies South Africa Virology HIV Seropositivity medicine Humans Sex organ Nonoxynol-9 Human papillomavirus Papillomaviridae Gynecology Vaginal microbicide Papillomavirus Infections HPV infection virus diseases Confounding Factors Epidemiologic medicine.disease Sex Work Administration Intravaginal Treatment Outcome Infectious Diseases DNA Viral Immunology HIV-1 Vaginal Creams Foams and Jellies Female medicine.drug Cohort study |
| Zdroj: | Virus Research. 121:220-222 |
| ISSN: | 0168-1702 |
| DOI: | 10.1016/j.virusres.2006.04.009 |
| Popis: | This study investigated the effectiveness of a nonoxynol-9 (52.5mg, 3.5%), vaginal gel (Advantage S), in the prevention of human papillomavirus (HPV) infection in female sex workers. We showed by HPV DNA determination in cervico-vaginal rinses a significant increase in multiple (>1) HPV infection in HIV-1 seropositive women compared with HIV-1 seronegative women (OR 4.0, 95% CI 1.3-11.9). We also demonstrated a significant increase in multiple HPV infections in HIV-1 seronegative women using nonoxynol-9 compared with HIV-1 seronegative women using placebo (OR 3.5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist. |
| Databáze: | OpenAIRE |
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