Therapy with a Purified Plasminogen Concentrate in an Infant with Ligneous Conjunctivitis and Homozygous Plasminogen Deficiency
| Autor: | Dorothee Schott, Carl-Erik Dempfle, Peter Beck, Andreas Liermann, Anita Mohr-Pennert, Michael Goldner, Peter Mehlem, Hiroyuki Azuma, Volker Schuster, Anne-Marie Mingers, Hans Peter Schwarz, Michael Dieter Kramer, Hans Liesenhoff, Karl Heinz Niessen |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Eye disease Respiratory System Restriction Mapping Disease Ligneous conjunctivitis medicine Humans Point Mutation Wound Healing Viscosity business.industry Nasopharyngitis Homozygote Infant Newborn Plasminogen Sequence Analysis DNA General Medicine Conjunctivitis medicine.disease Dermatology Blood Coagulation Factors Peptide Fragments Otitis Immunology Pseudomembranous Conjunctivitis medicine.symptom business Plasminogen deficiency Half-Life Hydrocephalus Rare disease |
| Zdroj: | New England Journal of Medicine. 339:1679-1686 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm199812033392305 |
| Popis: | Ligneous conjunctivitis is a rare disease characterized by acute or chronic recurrent conjunctivitis in which the conjunctival membranes acquire a wood-like consistency, due primarily to deposits of fibrin.1,2 Corneal involvement and chronic obstruction of the eye may lead to blindness. The disease is frequently associated with nasopharyngitis, tracheobronchial obstruction, otitis media, vulvovaginitis, and defective wound healing.2–9 Pseudomembranous conjunctivitis was first described in 1847 by Bouisson,10 and the term “conjunctivitis lignosa” was introduced by Borel in 1933.11 More than 100 cases have been reported in the literature, but no satisfactory treatment has yet been found. The results of therapy . . . |
| Databáze: | OpenAIRE |
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