Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification

Autor: Emilie Barruet, Edward C. Hsiao, Robert Dalton Chavez, Koji Matsuo
Rok vydání: 2019
Předmět:
0301 basic medicine
Receptors
Retinoic Acid
Endocrinology
Diabetes and Metabolism
Arthroplasty
Replacement
Hip
030209 endocrinology & metabolism
Inflammation
Adaptive Immunity
Article
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Immune system
Postoperative Complications
Blast Injuries
Brain Injuries
Traumatic
Stilbenes
Medicine
Animals
Humans
Janus Kinase Inhibitors
Mast Cells
Hypoxia
Spinal Cord Injuries
Sirolimus
business.industry
Macrophages
Ossification
Heterotopic
Anti-Inflammatory Agents
Non-Steroidal
Cell Differentiation
Mesenchymal Stem Cells
Hypoxia (medical)
medicine.disease
030104 developmental biology
Myositis Ossificans
Fibrodysplasia ossificans progressiva
Cancer research
Cytokines
Pyrazoles
Wounds and Injuries
Heterotopic ossification
Mesenchymal stem cell differentiation
Signal transduction
medicine.symptom
business
Burns
Immunosuppressive Agents
Signal Transduction
Zdroj: Curr Osteoporos Rep
ISSN: 1544-2241
Popis: PURPOSE OF REVIEW: Heterotopic ossification (HO) is associated with inflammation. The goal of this review is to examine recent findings on the roles of inflammation and the immune system in HO. We examine how inflammation triggers HO in fibrodysplasia ossificans progressiva, in traumatic HO, and in other clinical conditions of HO. We also discuss how inflammation may be a target for treating HO. RECENT FINDINGS: Both genetic and acquired forms of HO show similarities in their inflammatory cell types and signaling pathways. These include macrophages, mast cells, and adaptive immune cells; along with hypoxia signaling pathways, mesenchymal stem cell differentiation signaling pathways, vascular signaling pathways, and inflammatory cytokines. SUMMARY: Because there are common inflammatory mediators across various types of HO, these mediators may serve as common targets for blocking HO. Future research may focus on identifying new inflammatory targets and testing combinatorial therapies based on these results.
Databáze: OpenAIRE
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