Glutamate receptors and metaplasticity in addiction
| Autor: | Wickliffe C. Abraham, Cristiano Chiamulera, Alessandro Piva |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
n methyl dextro aspartic acid receptor 2A glutamate receptor Substance-Related Disorders media_common.quotation_subject Long-Term Potentiation cocaine Biology Nucleus accumbens 030226 pharmacology & pharmacy Synaptic Transmission 03 medical and health sciences 0302 clinical medicine Drug Discovery Metaplasticity medicine Humans media_common Pharmacology glutamic acid Neuronal Plasticity Addiction Glutamate receptor Long-term potentiation Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Receptors Glutamate Synaptic plasticity Glutamate receptor activity Neuroscience |
| Zdroj: | Current opinion in pharmacology. 56 |
| ISSN: | 1471-4973 |
| Popis: | Chronic drug use is a neuroadaptive disorder characterized by strong and persistent plasticity in the mesocorticolimbic reward system. Long-lasting effects of drugs of abuse rely on their ability to hijack glutamate receptor activity and long-term synaptic plasticity processes like long-term potentiation and depression. Importantly, metaplasticity-based modulation of synaptic plasticity contributes to durable neurotransmission changes in mesocorticolimbic pathways including the ventral tegmental area and the nucleus accumbens, causing 'maladaptive' drug memory and higher risk for drug-seeking relapse. On the other hand, drug-induced metaplasticity can make appetitive memories more malleable to modification, offering a potential target mechanism for intervention. Here we review the literature on the role of glutamate receptors in addiction-related metaplasticity phenomena. |
| Databáze: | OpenAIRE |
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