Interleukin-10 downregulates protective immunity to Brucella abortus
| Autor: | C. L. Baldwin, D M Fernandes |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Immunology Brucella abortus Down-Regulation Spleen Brucella Biology Monoclonal antibody Microbiology Neutralization Brucellosis Interferon-gamma Mice Immune system Th2 Cells Neutralization Tests medicine Animals Interferon gamma B-Lymphocytes Mice Inbred BALB C Macrophages biology.organism_classification Virology Interleukin-10 Interleukin 10 Infectious Diseases medicine.anatomical_structure Cytokine Chronic Disease Parasitology Female medicine.drug Research Article |
| Zdroj: | Infection and immunity. 63(3) |
| ISSN: | 0019-9567 |
| Popis: | In vivo neutralization of interleukin-10 (IL-10) with an anti-IL-10 monoclonal antibody resulted in up to 10-fold fewer bacteria in the spleens of BALB/c mice infected with the virulent Brucella abortus strain 2308. In vitro neutralization of endogenous IL-10 in brucella antigen-stimulated cultures of splenocytes from infected mice resulted in increased gamma interferon production in these cultures, whereas exogenous recombinant IL-10 inhibited the ability of peptone-elicited peritoneal macrophages to control intracellular brucellae. These data suggest that IL-10 may be downregulating the immune response to B. abortus by affecting both macrophage effector function and the production of the protective Th1 cytokine gamma interferon. |
| Databáze: | OpenAIRE |
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