Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Autor: Di Giambenedetto, S, Prosperi, M, Fanti, I, Bruzzone, B, Paolucci, S, Penco, G, Meini, G, Di Biagio, A, Paolini, E, Micheli, V, Meraviglia, P, Castelli, P, Corsi, P, Gonnelli, A, Fabbiani, M, Zazzi, M, De Luca, A, on behalf of the ARCA Collaborative Group, Consolini, Rita
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Databases
Factual
medicine.medical_treatment
Human immunodeficiency virus (HIV)
Drug resistance mutations
Drug Resistance
HIV Infections
Drug resistance
medicine.disease_cause
Logistic regression
Nucleoside Reverse Transcriptase Inhibitor
0302 clinical medicine
Antiretroviral Therapy
Highly Active
Prevalence
030212 general & internal medicine
Viral
Treatment Failure
Human immunodeficiency virus-1
media_common
0303 health sciences
General Medicine
Middle Aged
3. Good health
Antiretroviral therapy
Adult
Anti-HIV Agents
Drug Resistance
Viral
Female
Humans
Italy
Logistic Models
HIV-1
Infectious Diseases
Drug
Microbiology (medical)
medicine.medical_specialty
media_common.quotation_subject
Antiretroviral Therapy
Settore MED/17 - MALATTIE INFETTIVE
03 medical and health sciences
Databases
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
medicine
Highly Active
Factual
Protease
030306 microbiology
business.industry
medicine.disease
Virology
National database
business
Zdroj: Clinical Microbiology and Infection; Vol 17
Popis: We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007–2009 in the Italian national HIV drug resistance database ‘ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
Databáze: OpenAIRE
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