A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study
| Autor: | Alexis Luna, Maricruz de la Fuente, Amador Ruiz, Nuria Vilarrasa, Albert Lecube, Andreu Simó-Servat, Ramon Vilallonga, Cristina Hernández, Mercedes Rigla, Eduardo Salas, Enzamaria Fidilio, Silvia Pellitero, Andreea Ciudin, Assumpta Caixàs, Rafael Simó, Liliana Gutiérrez-Carrasquilla, Enric Sánchez |
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| Přispěvatelé: | Institut Català de la Salut, [Ciudin A, Hernández C, Simó R] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. [Fidilio E] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gutiérrez-Carrasquilla L] Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain. [Caixàs A] Endocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Medicine Department, Universitat Autònoma de Barcelona, Institut d’Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain. Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. [Vilarrasa N] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. Department of Endocrinology, Diabetes and Nutrition, Bellvitge University Hospital-IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain. [Pellitero S] Endocrine and Nutrition Department, Germans Trias i Pujol University Hospital, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain. [Vilallonga R, Ruiz A] Unitat de Cirurgia Endocrina, Metabòlica i Bariàtrica, Servei de Cirurgia General i Digestiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Center of Excellence for the EAC-BS, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
obesity
bariatric surgery weight loss genetics polygenic risk medicine.medical_specialty Weight loss Therapeutics::Obesity Management::Bariatrics::Bariatric Surgery [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Obesitat mòrbida Medicine (miscellaneous) Single-nucleotide polymorphism Article Aprimament terapéutica::manejo de la obesidad::bariatría::cirugía bariátrica [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Obesitat - Cirurgia Diabetes mellitus medicine Genetics Obesity Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity Morbid [DISEASES] enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad::obesidad mórbida [ENFERMEDADES] Genetic testing Bariatric surgery medicine.diagnostic_test Receiver operating characteristic Cirurgia Pathological Conditions Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight Loss [DISEASES] business.industry Polygenic risk afecciones patológicas signos y síntomas::signos y síntomas::peso corporal::cambios en el peso corporal::pérdida de peso [ENFERMEDADES] INSIG2 medicine.disease Surgery Medicine Obesitat Personalized medicine medicine.symptom business Genètica |
| Zdroj: | Scientia Journal of Personalized Medicine; Volume 11; Issue 10; Pages: 1040 Repositorio Abierto de la UdL Universitad de Lleida Journal of Personalized Medicine Dipòsit Digital de la UB Universidad de Barcelona Journal of Personalized Medicine, Vol 11, Iss 1040, p 1040 (2021) |
| Popis: | Genética; Obesidad; Pérdida de peso Genetics; Obesity; Weight loss Genètica; Obesitat; Pèrdua de pes Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. This research was supported by grants from the “Pla Estratègic de Recerca i Innovació en Salut” (PERIS) 2016–2020 (SLT002/16/00497), the Instituto de Salud Carlos III (PI PI18/00964), Fondos FEDER “Una manera de hacer Europa”), and Menarini España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) is an initiative of the Instituto Carlos III. |
| Databáze: | OpenAIRE |
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