Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol
| Autor: | Michael J. Durcan, Richard G. Lister, Markku Linnoila |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Benzylamines medicine.drug_class medicine.medical_treatment Pharmacology toxicology Pharmacology Motor Activity Locomotor activity Anxiolytic chemistry.chemical_compound Mice medicine Animals Drug Interactions Ethanol Behavior Animal Dose-Response Relationship Drug Chemistry Phenylethanolamine N-Methyltransferase Benzazepines Phenylethanolamine N-methyltransferase Stimulant Anxiogenic Exploratory Behavior Ataxia |
| Zdroj: | Psychopharmacology. 101(2) |
| ISSN: | 0033-3158 |
| Popis: | The centrally active inhibitors of phenylethanolamine-N-methyltransferase (PNMT), LY 78335 and LY 134046, were investigated both alone and in combination with ethanol (2 g/kg) in a holeboard test of directed exploration and locomotor activity. Both PNMT inhibitors showed dose-related reductions in exploratory head-dipping but were without effect on locomotor activity. In combination with ethanol both PNMT inhibitors tended to attenuate the ethanol-induced reductions in exploratory head-dipping but did not effect ethanol's locomotor stimulant properties. LY 134046 showed neither an anxiolytic nor an anxiogenic profile in the plus-maze test of anxiety, nor did it alter the anxiolytic effects of either 1.2 g/kg or 2 g/kg ethanol. LY 134046 did, however, attenuate the ataxic effects of a 2.4 g/kg dose of ethanol. These results may suggest a role for adrenaline synthesis in some, but not all, of the behavioral effects of ethanol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink