Robot-assisted gait training is not superior to intensive overground walking in multiple sclerosis with severe disability (the RAGTIME study): A randomized controlled trial

Autor: Elisa Maietti, Nino Basaglia, Sofia Straudi, Nicola Lamberti, Carlotta Martinuzzi, Fabio Manfredini
Rok vydání: 2019
Předmět:
Adult
Male
030506 rehabilitation
medicine.medical_specialty
medicine.medical_treatment
LS5_11
Walking
law.invention
NO
rehabilitation
03 medical and health sciences
0302 clinical medicine
Gait (human)
Physical medicine and rehabilitation
Gait training
Randomized controlled trial
law
Outcome Assessment
Health Care
medicine
Humans
Single-Blind Method
Severe disability
Gait Disorders
Neurologic
Progressive multiple sclerosis
Mobility
Rehabilitation
training
exercise
business.industry
Multiple sclerosis
Overground walking
Robotics
Middle Aged
Multiple Sclerosis
Chronic Progressive
medicine.disease
robot-assisted gait training
Exercise Therapy
Walking Speed
motor recovery
progressive multiple sclerosis
Neurology
Female
Neurology (clinical)
0305 other medical science
business
Mobility
motor recovery
progressive multiple sclerosis
rehabilitation
robot-assisted gait training
exercise
training
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Multiple sclerosis (Houndmills, Basingstoke, England). 26(6)
ISSN: 1477-0970
Popis: Background:Rehabilitation may attenuate the impact on mobility of patients with progressive multiple sclerosis (MS) and severe gait disabilities.Objective:In this randomized controlled trial, we compared robot-assisted gait training (RAGT) with conventional therapy (CT) in terms of gait speed, mobility, balance, fatigue and quality of life (QoL).Methods:Seventy-two patients with MS (expanded disability status scale score 6.0–7.0) were randomized to receive 12 training sessions over a 4-week period of RAGT ( n = 36) or overground walking therapy ( n = 36). The primary outcome was gait speed, assessed by the timed 25-foot walk test. Secondary outcome measures were walking endurance, balance, depression, fatigue and QoL. Tests were performed at baseline, intermediate, at the end of treatment and at a 3-month follow-up.Results:Sixty-six patients completed the treatments. At the end of treatment with respect to baseline, both groups significantly improved gait speed ( p Conclusions:RAGT was not superior to CT in improving gait speed in patients with progressive MS and severe gait disabilities where a positive, even transitory, effect of rehabilitation was observed.
Databáze: OpenAIRE
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