Flavonoid intakes inversely associate with COPD in smokers
| Autor: | Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyrø, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
RISK
Pulmonary and Respiratory Medicine Flavonoids Male DECLINE Smokers Incidence WOMEN food and beverages OBSTRUCTIVE PULMONARY-DISEASE Diet Pulmonary Disease Chronic Obstructive PROSPECTIVE COHORT INFLAMMATION CIGARETTE-SMOKE Risk Factors Humans Female Prospective Studies OXIDATIVE STRESS Pulmonary Disease Chronic Obstructive/epidemiology Follow-Up Studies |
| Zdroj: | Bondonno, N P, Parmenter, B H, Dalgaard, F, Murray, K, Rasmussen, D B, Kyrø, C, Cassidy, A, Bondonno, C P, Lewis, J R, Croft, K D, Gislason, G, Scalbert, A, Tjønneland, A, Overvad, K, Olsen, A & Hodgson, J M 2022, ' Flavonoid intakes inversely associate with COPD in smokers ', European Respiratory Journal. Supplement, vol. 60, no. 2, 2102604 . https://doi.org/10.1183/13993003.02604-2021 Bondonno, N P, Parmenter, B H, Dalgaard, F, Murray, K, Rasmussen, D B, Kyrø, C, Cassidy, A, Bondonno, C P, Lewis, J R, Croft, K D, Gislason, G, Scalbert, A, Tjonneland, A, Overvad, K, Olsen, A & Hodgson, J M 2022, ' Flavonoid intakes inversely associate with COPD in smokers ', European Respiratory Journal. Supplement, vol. 60, no. 2, 2102604 . https://doi.org/10.1183/13993003.02604-2021 |
| DOI: | 10.1183/13993003.02604-2021 |
| Popis: | Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters;however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This studyaimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) majorflavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.Methods This prospective cohort included 55 413 men and women without COPD, aged 50–65 years atrecruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaireusing Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD.Associations were modelled using restricted cubic splines within Cox proportional hazards models.Results During 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 werecurrent smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments,participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with thelowest intakes (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74–0.87); a 6–22% lower risk wasobserved for each flavonoid subclass. The inverse association between total flavonoid intake and COPDwas present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70–0.84) andformer smokers (HR 0.82, 95% CI 0.69–0.97), not never-smokers. Furthermore, higher flavonoid intakesappeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.Conclusion Dietary flavonoids may be important for partially mitigating the risk of smoking-relatedCOPD. However, smoking cessation should remain the highest priority Introduction Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.Methods This prospective cohort included 55 413 men and women without COPD, aged 50-65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled using restricted cubic splines within Cox proportional hazards models.Results During 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 were current smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments, participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with the lowest intakes (quintile 5 versus quintile 1: HR 0.80, 95% CI 0.74-0.87); a 6-22% lower risk was observed for each flavonoid subclass. The inverse association between total flavonoid intake and COPD was present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70-0.84) and former smokers (HR 0.82, 95% CI 0.69-0.97), not never-smokers. Furthermore, higher flavonoid intakes appeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.Conclusion Dietary flavonoids may be important for partially mitigating the risk of smoking-related COPD. However, smoking cessation should remain the highest priority. |
| Databáze: | OpenAIRE |
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