Progression of neuroanatomical abnormalities after first-episode of psychosis: A 3-year longitudinal sMRI study
Autor: | Gareth J. Barker, John McFarland, Cathy Scanlon, Theophilus N. Akudjedu, Colm McDonald, Giulia Tronchin, Dara M. Cannon, Peter McCarthy, Shane McInerney, Brian Hallahan, Joanne Kenney |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Longitudinal study Psychosis medicine.medical_treatment Thalamus 03 medical and health sciences 0302 clinical medicine Internal medicine Image Processing Computer-Assisted medicine Humans In patient Longitudinal Studies Antipsychotic Biological Psychiatry First episode business.industry Putamen medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Schizophrenia Cardiology business 030217 neurology & neurosurgery Antipsychotic Agents |
Zdroj: | Journal of Psychiatric Research. 130:137-151 |
ISSN: | 0022-3956 |
Popis: | The location, extent and progression of longitudinal morphometric changes after first-episode of psychosis (FEP) remains unclear. We investigated ventricular and cortico-subcortical regions over a 3-year period in FEP patients compared with healthy controls. High resolution 1.5T T1-weighted MR images were obtained at baseline from 28 FEP patients at presentation and 28 controls, and again after 3-years. The longitudinal FreeSurfer pipeline (v.5.3.0) was used for regional volumetric and cortical reconstruction image analyses. Repeated-measures ANCOVA and vertex-wise linear regression analyses compared progressive changes between groups in subcortical structures and cortical thickness respectively. Compared with controls, patients displayed progressively reduced volume of the caudate [F (1,51)=5.86, p=0.02, Hedges’ g=0.66], putamen [F (1,51)=6.06, p=0.02, g=0.67], thalamus [F (1,51)=6.99, p=0.01, g=0.72] and increased right lateral ventricular volume [F (1, 51)=4.03, p=0.05], and significantly increased rate of cortical thinning [F (1,52)=5.11, p=0.028)] at a mean difference of 0.84% [95% CI (0.10, 1.59)] in the left lateral orbitofrontal region over the 3-year period. In patients, greater reduction in putamen volume over time was associated with lower cumulative antipsychotic medication dose (r=0.49, p=0.01), and increasing lateral ventricular volume over time was associated with worsening negative symptoms (r=0.41, p=0.04) and poorer global functioning (r= −0.41, p=0.04). This study demonstrates localised progressive structural abnormalities in the cortico-striato-thalamo-cortical circuit after the onset of psychosis, with increasing ventricular volume noted as a neuroanatomical marker of poorer clinical and functional outcome. |
Databáze: | OpenAIRE |
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