Cytoplasmic crystalloids in irradiated rat parotid glands
| Autor: | Marvin Sodicoff, Milton M. Sholley, N.E. Pratt |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Time Factors Vacuole Biology Cytoplasmic Granules Pathology and Forensic Medicine chemistry.chemical_compound Basal (phylogenetics) Lysosome medicine Animals Parotid Gland Ethionine Macrophages Autophagy Rats Inbred Strains Rats medicine.anatomical_structure Otorhinolaryngology chemistry Cytoplasm Ultrastructure Periodontics Female Oral Surgery Crystallization Rat Parotid |
| Zdroj: | Journal of Oral Pathology and Medicine. 10:192-202 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/j.1600-0714.1981.tb01265.x |
| Popis: | Cytoplasmic crystalloids were found in parotid acinar cells of rats given a large (6400 R) single exposure of X-rays to the head and neck. The crystalloids were first observed 1 day after irradiation and became numerous at 3-4 days. They were associated with autophagic vacuoles, which were seen in acinar cells as early as 3-6 h. Crystalloids sometimes appeared to be forming within autophagic vacuoles, which also contained membranous residues and apparently degenerating secretory material. They were bounded by a single smooth membrane and had a substructure consisting of dense, parallel longitudinal striations. They crystalloids were also seen in macrophages associated with the basal surface of acinar cells. At 3-4 days macrophages were numerous and many contained crystalloids, degenerated secretory droplets, and other cellular debris, which they apparently had phagocytosed. By 6-8 days crystalloids and macrophages were seen infrequently. Regarding mode of formation, removal by macrophages, and ultrastructure, the crystalloids resembled those described by others after ethionine intoxication. Ethionine-induced crystalloids have cytochemical characteristics consistent with a lysosomal identity. The crystalloids in irradiated parotid glands probably reflect a variant type of lysosome, which is a nonspecific manifestation of severe cellular injury and can be elicited by a variety of injurious agents. |
| Databáze: | OpenAIRE |
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