Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment
| Autor: | Emmanuel O. Akala, Oleg Bol'shakov, Winston A. Anderson, Namita Kumari, Ayele Gugssa, Oluwaseun Ogunwuyi, Kahli A. Smith, Sergei Nekhai, Simeon K. Adesina |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Drug
Nevirapine media_common.quotation_subject CEM T cells 02 engineering and technology Bioinformatics 030226 pharmacology & pharmacy Peripheral blood mononuclear cell lcsh:Infectious and parasitic diseases 03 medical and health sciences Zidovudine ARV drugs 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) immune system diseases GALT Medicine lcsh:RC109-216 Original Research media_common business.industry Lamivudine virus diseases 021001 nanoscience & nanotechnology Raltegravir medicine.disease Virology 3. Good health PBMCs Drug delivery dispersion polymerization nanoparticles 0210 nano-technology business medicine.drug |
| Zdroj: | Infectious Diseases, Vol 2016, Iss 9, Pp 21-32 (2016) Infectious Diseases, Vol 9 (2016) Infectious Diseases |
| ISSN: | 1178-6337 |
| Popis: | Highly active antiretroviral (ARV) therapy (HAART) for chronic suppression of HIV replication has revolutionized the treatment of HIV/AIDS. HAART is no panacea; treatments must be maintained for life. Although great progress has been made in ARV therapy, HIV continues to replicate in anatomical and intracellular sites where ARV drugs have restricted access. Nanotechnology has been considered a platform to circumvent some of the challenges in HIV/AIDS treatment. Dispersion polymerization was used to fabricate two types (PMM and ECA) of polymeric nanoparticles, and each was successfully loaded with four ARV drugs (zidovudine, lamivudine, nevirapine, and raltegravir), followed by physicochemical characterization: scanning electron microscope, particle size, zeta potential, drug loading, and in vitro availability. These nanoparticles efficiently inhibited HIV-1 infection in CEM T cells and peripheral blood mononuclear cells; they hold promise for the treatment of HIV/AIDS. The ARV-loaded nanoparticles with polyethylene glycol on the corona may facilitate tethering ligands for targeting specific receptors expressed on the cells of HIV reservoirs. |
| Databáze: | OpenAIRE |
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