Correlation between F18-FDG PET/CT Imaging and BRAF V600E Genetic Mutation for the Early Assessment of Treatment Response in Papillary Thyroid Cancers
| Autor: | Doina Piciu, Andra Piciu, Maria-Iulia Larg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Medicine (miscellaneous) lcsh:Medicine 030209 endocrinology & metabolism medicine.disease_cause Article Papillary thyroid cancer 03 medical and health sciences SUV PET/CT 0302 clinical medicine Internal medicine medicine papillary thyroid cancer Stage (cooking) Pathological Oncogene medicine.diagnostic_test business.industry BRAF V600E Thyroid lcsh:R medicine.disease medicine.anatomical_structure Positron emission tomography 030220 oncology & carcinogenesis Thyroglobulin Carcinogenesis business |
| Zdroj: | Journal of Personalized Medicine, Vol 10, Iss 52, p 52 (2020) Journal of Personalized Medicine Volume 10 Issue 2 |
| ISSN: | 2075-4426 |
| Popis: | In thyroid neoplastic pathology, the BRAF V600E mutation is shown to be involved in the oncogenesis of papillary thyroid cancer and its subtypes. The purpose of this study is to evaluate the correlation between the mutation of the BRAF V600E oncogene and the pathological standardized uptake values (SUV) at the F18-fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) evaluation, for a group of 20 patients with radically treated (total thyroidectomy and radioiodine therapy) papillary thyroid cancer, with subclinical persistent disease, at 6 months after the initial treatment. We analyzed the correlations between the values of SUV and the presence of the BRAF mutation as well with other prognostic factors such as stage, age, specific tumor markers (thyroglobulin and anti-thyroglobulin), extrathyroid extension, the presence of metastatic lymph nodes or distant metastasis. The value of SUV in the case of BRAF+ (positive) patients was higher than in the negative ones, but without statistical significance, thus, the values of the SUV cannot be a predictable factor for the presence of the genetic mutation. There was a statistically significant correlation in BRAF+ subgroup between the SUV values and the positive resection limit following surgery, showing a higher SUV value in the PET/CT evaluation. No correlation was observed between the aforementioned prognostic factors involved in papillary thyroid cancer and the BRAF V600E mutation. |
| Databáze: | OpenAIRE |
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