Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism
| Autor: | Murat Meric, Atilla Guven Atici, Yıldıray Çelenk, Türker Yardan, Celal Kati |
|---|---|
| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Erythrocyte Indices
Male Medicine (General) Pediatrics Ventricular Dysfunction Right Early death 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Severity of Illness Index Leukocyte Count 0302 clinical medicine Risk Factors Platelet 030212 general & internal medicine Right ventricular dysfunction Medicine(all) Receiver operating characteristic analysis Middle Aged Prognosis Pulmonary embolism Echocardiography Acute Disease Risk stratification Cardiology White blood cells Female Adult Risk medicine.medical_specialty Adolescent Mean platelet volume Red cell distribution width Statistics Nonparametric Young Adult 03 medical and health sciences R5-920 medicine.artery Internal medicine Severity of illness medicine Humans Aged Retrospective Studies Receiver operating characteristic Platelet Count business.industry Retrospective cohort study Red blood cell distribution width medicine.disease Surgery Poster Presentation Automotive Engineering Pulmonary artery business |
| Zdroj: | Medicina; Volume 52; Issue 2; Pages: 110-115 Medicina Volume 52 Issue 2 Pages 110-115 Medicina, Vol 52, Iss 2, Pp 110-115 (2016) Critical Care |
| ISSN: | 1648-9144 |
| DOI: | 10.1016/j.medici.2016.03.001 |
| Popis: | 35th International Symposium on Intensive Care and Emergency Medicine -- MAR 17-20, 2015 -- Brussels, BELGIUM WOS: 000375851300006 PubMed: 27170484 Background and objective: Recently, some of the hemogram parameters were reported to predict early death in acute pulmonary embolism (PE). The aim of this study was to investigate the role of mean platelet volume (MPV) and MPV/platelet count ratio (MPV/P), WBC and red cell distribution width (RDW) in risk stratification of patients with acute PE. Materials and methods: We retrospectively reviewed the medical records of patients with acute PE admitted to the Emergency Department. In addition to the clinical evaluation, the hemogram parameters were measured on admission. Results: A total of 152 patients were included. Patients with RV dysfunction had significantly higher MPV levels and MPV/P than patients without RV dysfunction. Receiver operating characteristic curve analysis revealed thata MPV cut-off of 7.85 fL provided a sensitivity of 53.3% and a specificity of 68.5%, and a MPV/P cut-off of 0.0339 fL/(109/L) provided a sensitivity of 69.6% and a specificity of 65% for the prediction of RV dysfunction. There was a positive correlation between MPV and systolic pulmonary artery pressure (SPAP) and between MPV and RV diameter. There was a positive correlation between MPV/P and SPAP and between MPV/P and RV diameter. The low-risk PE group had lower MPV and MPV/P than the massive PE and submassive PE groups. Conclusions: MPV and MPV/P were found to be associated with RV dysfunction and clinical severity in acute PE. Low MPV and MPV/P levels may be an indicator of low risk and, high WBC levels may be an indicator of high risk in patients with acute PE. RDW levels may not reflect severity of acute PE. (C) 2016 The Lithuanian University of Health Sciences. Production and hosting by Elsevier B.V. |
| Databáze: | OpenAIRE |
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