Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study
| Autor: | André Nadeau, Arthur S. Leon, Jacques Gagnon, Jean-Pierre Després, James S. Skinner, Louis Pérusse, Claude Bouchard, Treva Rice, Jack H. Wilmore, D. C. Rao, Jean Bergeron, Yuling Hong |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Genes Recessive Locus (genetics) Biology Genetic determinism Insulin resistance Gene Frequency Internal medicine medicine Humans Insulin Genetic Predisposition to Disease Exercise Allele frequency Aged Genes Dominant Genetics Lipoprotein lipase Models Genetic Chromosome Mapping Middle Aged medicine.disease Obesity Major gene Lipoprotein Lipase Phenotype Endocrinology Female lipids (amino acids peptides and proteins) Insulin Resistance Cardiology and Cardiovascular Medicine |
| Zdroj: | Atherosclerosis. 144:393-401 |
| ISSN: | 0021-9150 |
| Popis: | A major gene hypothesis for heparin releasable plasma lipoprotein lipase (PH-LPL) activity was assessed using segregation analyses of data on 495 members in 98 normolipidemic sedentary families of Caucasian descent who participated in the HERITAGE Family Study. Segregation analyses were performed on PH-LPL adjusted for age, and on PH-LPL activity adjusted for age and fasting insulin. Prior to adjustment for insulin, neither a major gene effect nor a multifactorial component could be rejected, and support for a major gene was equivocal i.e. neither the Mendelian transmission nor the no transmission (equal tau s) models were rejected. However, after adjusting for the effects of insulin, a major gene effect on PH-LPL activity was unambiguous. The putative locus accounted for 60% of the total phenotypic variance, and the homozygous recessive form affected 10% (q2) of the sample (i.e. gene frequency (q) = 0.31), and led to a low PH-LPL value. The lack of a significant multifactorial effect suggested that the familial etiology of PH-LPL activity adjusted for insulin was likely to be primarily a function of the major locus. In conclusion, the present study is the first to report segregation analyses on PH-LPL activity prior to and after adjusting for insulin, and suggests that there is an indication of a pleiotropic genetic effect on PH-LPL activity and insulin, in addition to a major gene effect on PH-LPL activity alone. |
| Databáze: | OpenAIRE |
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