A genome wide scan for association with multiple sclerosis in a N. Irish case control population
| Autor: | Michael Hutchinson, Colin A. Graham, Alastair Compston, Koen Vandenbroeck, A. G. Droogan, G V McDonnell, Stephen Sawcer, Stanley Hawkins, Shirley Heggarty, Efrosini Setakis |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Candidate gene Linkage disequilibrium Multiple Sclerosis Genotype International Cooperation Immunology Northern Ireland Biology Polymerase Chain Reaction Genome Gene Frequency Humans Immunology and Allergy Genetic Predisposition to Disease Genetic Testing Typing Association mapping Gene Alleles Genetics Genome Human Electrophoresis Capillary Chromosome Genetics Population Neurology Case-Control Studies Microsatellite Female Neurology (clinical) Microsatellite Repeats |
| Zdroj: | Journal of Neuroimmunology. 143:93-96 |
| ISSN: | 0165-5728 |
| Popis: | In order to screen the genome for linkage disequilibrium (LD) in multiple sclerosis (MS), we typed 2537 microsatellite markers in separately pooled DNA from 200 cases and 200 controls from N. Ireland. Twenty two markers showing significant evidence of association were identified including three from the HLA region on chromosome 6p21. Putative candidate genes mapping close to the 19 novel markers include the IL10RA and CD3E genes on 11q23 (which both lie close to the marker D11S1998). Individual typing of the marker D11S1998 confirmed its association. |
| Databáze: | OpenAIRE |
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