Age-Related Blood Pressure Sensitivity to Aldosterone in Blacks and Whites
| Autor: | Wanzhu Tu, Vivek Bhalla, Ruohong Li, George J. Eckert, J. Howard Pratt |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Blood Pressure 030204 cardiovascular system & hematology Plasma volume White People Renin-Angiotensin System Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Age related Renin–angiotensin system Internal Medicine medicine Humans Prospective Studies Child Aldosterone business.industry Incidence Prognosis United States Black or African American 030104 developmental biology Endocrinology Blood pressure chemistry Child Preschool Hypertension Female business Biomarkers Follow-Up Studies |
| Zdroj: | Hypertension. 72:247-252 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Aldosterone sensitivity, defined as the magnitude of the association of plasma aldosterone concentration with blood pressure (BP), seems to be a function of plasma volume. It increases as plasma renin activity decreases, and it is more significant in blacks but less so in whites. Age is a strong determinant of BP, and an increase in aldosterone sensitivity could contribute to the increase in BP. In the present study, we tested the hypothesis that aldosterone sensitivity increases with age. We used observational data collected from normotensive blacks and whites enrolled in a prospective cohort study. They were studied as children (248 blacks/357 whites) and again as young adults (74 blacks/125 whites) over an age range of 7 to 39 years. A varying-coefficient regression analysis was used to explore the influences of aldosterone on systolic BP. After controlling for body mass index, race, and sex, both plasma renin activity and plasma aldosterone concentration were lower in blacks, and their levels declined with age ( P P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|