Sex Differences in Pulmonary Responses to Ozone in Mice. Role of the Microbiome
| Autor: | Hiroki Tashiro, Traci A. Brown, Galeb Abu-Ali, Ross S. Osgood, Youngji Cho, David I. Kasahara, Curtis Huttenhower, Stephanie A. Shore |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine medicine.drug_class Clinical Biochemistry Antibiotics Biology 03 medical and health sciences Ozone Sex Factors 0302 clinical medicine Respiratory Hypersensitivity medicine Animals Microbiome Lung Molecular Biology Asthma trigger Original Research Microbiota Cell Biology Fatty Acids Volatile Gut microbiome Anti-Bacterial Agents Mice Inbred C57BL 030104 developmental biology 030228 respiratory system Immunology 16s rrna gene sequencing Female Propionates Bronchoalveolar Lavage Fluid Airway responsiveness |
| Zdroj: | American Journal of Respiratory Cell and Molecular Biology. 60:198-208 |
| ISSN: | 1535-4989 1044-1549 |
| DOI: | 10.1165/rcmb.2018-0099oc |
| Popis: | We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short-chain fatty acids, end products of bacterial fermentation, likely contribute to this role of the microbiome. A growing body of evidence indicates that there are sex-related differences in gut microbiota and these differences can have important functional consequences. The purpose of this study was to determine whether there are sex-related differences in the impact of the gut microbiota on pulmonary responses to ozone. After acute exposure to ozone, male mice developed greater airway hyperresponsiveness than female mice. This difference was abolished after antibiotic ablation of the gut microbiome. Moreover, weanling female pups housed in cages conditioned by adult male mice developed greater ozone-induced airway hyperresponsiveness than weanling female pups raised in cages conditioned by adult females. Finally, ad libitum oral administration via drinking water of the short-chain fatty acid propionate resulted in augmented ozone-induced airway hyperresponsiveness in male, but not female, mice. Overall, these data are consistent with the hypothesis that the microbiome contributes to sex differences in ozone-induced airway hyperresponsiveness, likely as a result of sex differences in the response to short-chain fatty acids. |
| Databáze: | OpenAIRE |
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