The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics
| Autor: | Barbara Casadei, Alison M Fletcher, P Manley, V Ferreira, S Neubauer, Guilherme Pessoa-Amorim, Aaron T. Hess, Jemma C. Hopewell, A Stracquadanio, Rohan S. Wijesurendra, A Von Ende, Marco Spartera |
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| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty left atrial myopathy 4D flow CMR medicine.medical_treatment Diastole Cardioversion Stroke risk cardioversion Left atrial Risk Factors Internal medicine Atrial Fibrillation medicine Humans Radiology Nuclear Medicine and imaging Sinus rhythm Atrial Appendage AcademicSubjects/MED00200 business.industry Atrial fibrillation General Medicine Blood flow medicine.disease stroke risk Original Papers Stroke Cardiology Atrial Function Left Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal Cardiovascular Imaging |
| ISSN: | 2047-2412 |
| Popis: | Aims Altered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk in atrial fibrillation (AF). Here, we aimed to assess whether exposure to stroke risk factors is sufficient to alter LA blood flow even in the presence of sinus rhythm (SR). Methods and results We investigated 95 individuals: 37 patients with persistent AF, who were studied before and after cardioversion [Group 1; median CHA2DS2-VASc = 2.0 (1.5–3.5)]; 35 individuals with no history of AF but similar stroke risk to Group 1 [Group 2; median CHA2DS2-VASc = 3.0 (2.0–4.0)]; and 23 low-risk individuals in SR [Group 3; median CHA2DS2-VASc = 0.0 (0.0–0.0)]. Cardiac function and LA flow characteristics were evaluated using cardiac magnetic resonance. Before cardioversion, Group 1 displayed impaired left ventricular (LV) and LA function, reduced LA flow velocities and vorticity, and a higher normalized vortex volume (all P Graphical Abstract |
| Databáze: | OpenAIRE |
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