A case of Aspergillus fumigatus peritonitis complicating liver transplantation
| Autor: | Mark P. Wilhelm, Ruud A.F. Krom, K. Batts, Michael R. Keating, J. S. Sartin |
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| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Ganciclovir Male Pathology medicine.medical_specialty medicine.medical_treatment Peritonitis Liver transplantation Aspergillosis Aspergillus fumigatus Immunocompromised Host Postoperative Complications Intestine Small medicine Humans Mycosis biology business.industry General Medicine Hepatitis B Middle Aged medicine.disease biology.organism_classification Hepatitis D Liver Transplantation Transplantation Infectious Diseases business medicine.drug |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 13(1) |
| ISSN: | 0934-9723 |
| Popis: | A 55-year-old male underwent orthotopic liver transplantation for sub-fulminant hepatitis B/delta infection superimposed on probable genetic hemochromatosis with early cirrhosis. Pre-operatively, he demonstrated serologic evidence of cytomegalovirus reactivation and developed cytomegalovirus viremia when ganciclovir was discontinued post-operatively. His post-operative course was complicated by chronic ductopenic rejection, biliary anastomotic leak, and persistent confusion and malaise. At the time of laparotomy for repair of the bile leak, nodular peritoneal lesions were noted, with biopsy and culture showing angioinvasive Aspergillus fumigatus. Despite administration of amphotericin B, the patient continued to have culture-confirmed evidence of infection at follow-up peritoneoscopy. Oral itraconazole was begun, but the patient died of liver failure secondary to progressive ductolpenic rejection. At autopsy, Aspergillus organisms were seen in histologic sections taken from the small bowel; there was no evidence of disseminated disease. |
| Databáze: | OpenAIRE |
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