Age-related immune reconstitution during highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children
| Autor: | Cécile Alexandra Peltier, Jack Levy, Marc Hainaut, Georges Zissis, Liliane Schandené, Denise Marissens, Martine Ducarme, Françoise Mascart |
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| Rok vydání: | 2003 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Microbiology (medical) Cellular immunity Time Factors Adolescent Antigens CD19 CD4-CD8 Ratio Receptors Antigen T-Cell HIV Infections CD8-Positive T-Lymphocytes HIV Antibodies Virus Immune system Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Immunopathology Candida albicans Tetanus Toxoid Humans Medicine Protein Tyrosine Phosphatase Non-Receptor Type 1 biology business.industry Age Factors Infant virus diseases biology.organism_classification medicine.disease Virology Infectious Diseases Immunology Lentivirus Pediatrics Perinatology and Child Health HIV-1 Leukocyte Common Antigens Female Viral disease Mitogens business Viral load |
| Zdroj: | The Pediatric Infectious Disease Journal. 22:62-69 |
| ISSN: | 0891-3668 |
| Popis: | To evaluate the immune reconstitution in HIV-1-infected children in whom highly active antiretroviral therapy (HAART) controlled viral replication and to assess the existence of a relation between the magnitude of this restoration and age.All HIV-1-infected children in whom a new HAART decreased plasma viral load below 400 copies/ml after 3 months of therapy were prospectively enrolled in a study of their immune reconstitution. Viral load, lymphocyte phenotyping, determination of CD4+ and CD8+ T cell receptor repertoires and proliferative responses to mitogens and recall antigens were assessed every 3 months during 1 year.Nineteen children were evaluated. Naive and memory CD4+ percentages were already significantly increased after 3 months of HAART. In contrast to memory CD4+ percentages, naive CD4+ percentages continued to rise until 12 months. Age at baseline was inversely correlated with the magnitude of the rise in naive CD4+ cells after 3, 6 and 9 months of therapy but not after 12 months. Although memory and activated CD8+ cells were already decreasing after 3 months, abnormalities of the CD8 T cell receptor repertoire and activation of CD8+ cells persisted at 1 year. HAART increased the response to mitogens as early as 3 months after starting therapy.In children the recovery of naive CD4+ cells occurs more rapidly if treatment is started at a younger age, but after 1 year of viral replication control, patients of all ages have achieved the same level of restoration. Markers of chronic activation in CD8+ cells persist after 1 year of HAART. |
| Databáze: | OpenAIRE |
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