P300 in alcohol dependence: Effects of TaqI-A genotype
| Autor: | Janet Hoenicka, Tomás Palomo, G. Ponce, J. Rodríguez-Torresano, R. Rodriguez, Gabriel Rubio, Jiménez-Arriero |
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| Předmět: |
medicine.medical_specialty
congenital hereditary and neonatal diseases and abnormalities TaqI Abstinence business.industry Alcohol dependence Psychiatry and Mental health chemistry.chemical_compound Alcoholism Endophenotype Endocrinology TaqI-A1 chemistry Internal medicine Genotype Medicine P300 business Event-related potentials |
| Zdroj: | ResearcherID The European Journal of Psychiatry, Volume: 23, Issue: 4, Pages: 225-233, Published: DEC 2009 The European Journal of Psychiatry v.23 n.4 2009 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname |
| Popis: | Background and Objectives: TaqI-A polymorphism, related to D2 dopamine receptor (DRD2), and event-related P300 potentials have been considered markers of alcohol dependence. The effect of alcohol use variables and TaqI-A on P300 in a single sample have been hardly analysed previously. This study examined changes in P300 parameters after six months of abstinence in alcohol-dependent subjects classified by their TaqI-A genotype. Methods: 102 men with alcohol dependence were studied at baseline and at 6 months of continued abstinence. P300 was recorded using an auditory paradigm. TaqI-A polymorphism was genotyped: 34.3% of sample was classified as A1[TaqI-A1/TaqI-A1and TaqI-A1/TaqI-A2] and 65.7% as A2 [TaqI-A2/TaqI-A2]. The association between P300 and TaqI-A and the correlation with age and alcohol consumption were considered. Results: The abstinence period was not associated to differences in neither P300 latency (F[1, 99] = 1.154 p = 0.285) nor amplitude (F[1, 99] = 1.453, p = 0.231). A1 subgroup was related to a longer latency (F[1, 99] = 5.055 p = 0.027), an early abuse age onset (F[1, 100] = 14.552 p |
| Databáze: | OpenAIRE |
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