Comparison of the transmissibility of Trypanosoma congolense strains, isolated in a trypanosomiasis endemic area of eastern Zambia, by Glossina morsitans morsitans
| Autor: | Justin Masumu, Jozef Vercruysse, Tanguy Marcotty, Pierre Dorny, Stanny Geerts, N Ndeledje, P. Van den Bossche, C. Kubi |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Tsetse Flies Trypanosoma congolense Population Virulence Zambia Microbiology Mice Trypanosomiasis medicine Animals Parasite hosting Transmission education Life Cycle Stages education.field_of_study biology Trypanosomiasis Bovine Kinetoplastida Africa East Protozoal diseases medicine.disease biology.organism_classification Virology Insect Vectors Glossina morsitans morsitans Animal diseases Trypanosomiasis African Infectious Diseases Susceptible individual Trypanosoma Protozoa Cattle Animal Science and Zoology Parasitology |
| DOI: | 10.1017/S0031182006000369 |
| Popis: | Transmission experiments were conducted to compare the transmissibility of genetically differentTrypanosoma congolense(Savannah subgroup) strains isolated from cattle in a trypanosomiasis endemic area of eastern Zambia. A total of 17 strains were compared. Three strains were extremely virulent with a short pre-patent period, high parasitaemia and a short median survival time (between 5 and 9 days) in mice. The remainder of the strains belonged to the moderate (6 strains) or low (8 strains) virulence categories with median survival times between 10 and 30 days and >30 days, respectively. Batches of 40 teneralGlossina morsitans morsitans(Diptera: Glossinidae) were offered a single bloodmeal on mice infected with one of those strains. Flies were dissected to determine their infection status 21 days later. The proportion of flies with procyclic and metacyclic infections differed significantly between trypanosome strains and were significantly higher in flies infected with extremely virulent strains (P=0·033 andP=0·016 for the differences in the procyclic infection rate of strains with moderate and low virulence, respectively andP=0·005 andP=0·019 for the differences in the metacyclic infection rate of strains with moderate and low virulence, respectively). On the other hand, moderately virulent strains had, in general, higher procyclic and metacyclic infection rates compared to low virulent strains. But the differences were not significant (P>0·05). The outcome of those experiments shows clear differences in transmissibility of trypanosome strains associated with their virulence. This observation confirms the theory for the evolution and maintenance of virulence in a parasite population and may explain the persistence of virulent trypanosome strains in a susceptible host population. |
| Databáze: | OpenAIRE |
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