Impairment and reorganization of the phosphoinositide-specific phospholipase C enzymes in suicide brains
| Autor: | C. Della Rocca, Massimo Montisci, Martina Leopizzi, Paolo Fais, Vincenza Rita Lo Vasco, Giovanni Cecchetto |
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| Přispěvatelé: | Lo Vasco VR, Leopizzi, M, Della Rocca, C, Fais, Paolo, Montisci, M, Cecchetto |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Gene isoform
Human brain Phospholipase C Signal transduction Suicide Serotonin medicine.medical_specialty Phospholipase C beta Poison control suicide signal transduction human brain phospholipase C Phosphatidylinositols Polymerase Chain Reaction Gene Expression Regulation Enzymologic Pathogenesis Phosphoinositide Phospholipase C medicine Humans Psychiatry Phosphoric Diester Hydrolases business.industry Brain Immunohistochemistry Psychiatry and Mental health Clinical Psychology Signalling medicine.anatomical_structure Microscopy Fluorescence Female business Neuroscience |
| Popis: | A number of studies suggested that suicide may be associated with specific neurobiological abnormalities. Neurobiology studies focused upon abnormalities of signalling mechanisms with special regard to the serotonin system and the related Phosphoinositide (PI) signalling system. Previous data suggested the involvement of the PI-specific phospholipase C (PLC) family in neuropsychiatric disorders. By using PCR and morphological microscopy observation we examined the whole panel of expression of PLC isoforms in the brains of 28 individuals who committed suicide and in normal controls in order to evaluate the involvement of specific PLC isoforms. The overall PLC expression was reduced and a complex reorganization of the isoforms was observed. The knowledge of the complex network of neurobiological molecules and interconnected signal transduction pathways in the brain of suicide victims might be helpful to understand the natural history and the pathogenesis of the suicidal behavior. That might lead to obtain prognostic suggestions in order to prevent suicide and to new therapeutic agents targeting specific sites in this signalling cascade. |
| Databáze: | OpenAIRE |
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