Acute toxicity of T-2 toxin in broiler chicks and laying hens
| Autor: | W. Shimoda, M. S. Chi, H. J. Kurtz, G A Weaver, Chester J. Mirocha, H. R. Burmeister, F Y Bates |
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| Rok vydání: | 1977 |
| Předmět: |
Oviposition
Physiology Hematocrit medicine.disease_cause Median lethal dose Hemoglobins Seizures medicine Animals Aspartate Aminotransferases Coma Gizzard Poultry Diseases medicine.diagnostic_test business.industry Toxin Body Weight Broiler General Medicine Acute toxicity Diarrhea T-2 Toxin Cholesterol Animal Science and Zoology Female medicine.symptom business Weight gain Chickens Sesquiterpenes |
| Zdroj: | Poultry science. 56(1) |
| ISSN: | 0032-5791 |
| Popis: | Purified T-2 toxin was given to broiler chicks and laying hens in single oral doses by intubation into the crop to evaluate acute toxic effects. The 10-day median lethal dose for one-day-old broiler chicks in two experiments was estimated as 5.03 ± 0.25 and 5.25 ± 0.21 mg./kg. body weight. The 10-day median lethal dose for 8-week-old broiler chicks and laying hens was 4.97 ± 0.25 and 6.27 ± 0.42 mg./kg. body weight, respectively. Death of birds occurred within 48 hours after T-2 toxin administration. Within 4 hours after receiving T-2 toxin, birds developed asthenia, inappetence, diarrhea and panting. Coma was observed in birds given high lethal doses of T-2 toxin. The abdominal cavities of birds given lethal doses contained a white chalk-like material, which covered much of the viscera. Sublethal doses of T-2 toxin resulted in a decrease of weight gain and feed consumption which were proportional to the amount of the toxin given. No obvious abnormal changes in the bone marrow were noted in surviving birds. The blood components (hematocrit, hemoglobin, erythrocyte, leukocyte, SGOT, SGPT, serum LDH, serum alkaline phosphatase, serum total protein, serum cholesterol and serum uric acid) determined at 10 and 30 days after T-2 toxin administration were not significantly changed or not consistently changed in 8-week-old broiler chicks and laying hens by T-2 toxin. Other than necrotic visible lesions on the mucosal surface of the gizzard and crop in a few high dose birds, no salient pathological or clinical signs were observed at 10 and 30 days after T-2 toxin administration. |
| Databáze: | OpenAIRE |
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