In vitroAnti-tumor Activity of Anti-c-erbB-2 × Anti-CD3ɛ Bifunctional Monoclonal Antibody
| Autor: | Kenichi Imagawa, Takachika Azuma, Yoshihiro Sugiyama, Hidechika Okada, Ken Yamaguchi, Hiroshi Momota, Kyohei Deguchi, Mikio Kikuchi, Miki Aihara, Jiro Hitomi, Masafumi Shibamori, Ozge Alper |
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| Rok vydání: | 1992 |
| Předmět: |
Monoclonal antibody
Antigens Differentiation T-Lymphocyte Cytotoxicity Immunologic Cancer Research CD3 Complex Antibodies Neoplasm Receptor ErbB-2 medicine.drug_class T-Lymphocytes medicine.medical_treatment Cell Receptors Antigen T-Cell Cancer immunotherapy Anti‐CD3ɛ In Vitro Techniques Anti‐c‐erbB‐2 Gene product Immunoglobulin Fab Fragments Antigen Proto-Oncogene Proteins Tumor Cells Cultured medicine Humans Key words Bifunctional antibody Immunity Cellular Oncogene biology Antibodies Monoclonal Immunotherapy Cross-Linking Reagents medicine.anatomical_structure Oncology Immunology biology.protein Cancer research Antibody Rapid Communication |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c-erbB-2 gene product, and the other arm recognized CD3 epsilon, a T-cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti-tumor activity in vitro on a breast tumor cell line, ZR-75-1, which expressed abundant c-erbB-2 gene product on its cell surface. These results indicate that BFA recognizing an oncogene product on cell surface is a potential new agent for cancer immunotherapy. |
| Databáze: | OpenAIRE |
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