Deteriorated regional calf microcirculation measured by contrast-free MRI in patients with diabetes mellitus and relation with physical activity
| Autor: | Christopher J. Sorensen, Mohamed A. Zayed, Charles F. Hildebolt, Michael J. Mueller, Jie Zheng, Ran Li, Hongyu An, Mary K. Hastings |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Endocrinology Diabetes and Metabolism 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 0302 clinical medicine Surveys and Questionnaires Contrast (vision) Foot ulcers Prospective Studies media_common medicine.diagnostic_test Middle Aged Diabetic Foot medicine.anatomical_structure diabetes mellitus Cardiology Original Article Female Cardiology and Cardiovascular Medicine medicine.medical_specialty media_common.quotation_subject Perfusion Imaging Physical activity microcirculation Microcirculation 03 medical and health sciences Magnetic resonance imaging peripheral arterial disease Predictive Value of Tests Internal medicine Diabetes mellitus Internal Medicine medicine Humans In patient Ankle Brachial Index skeletal muscle Exercise Aged Glycated Hemoglobin Leg business.industry Skeletal muscle medicine.disease Regional Blood Flow Case-Control Studies business Biomarkers Diabetic Angiopathies |
| Zdroj: | Diabetes & Vascular Disease Research |
| ISSN: | 1752-8984 1479-1641 |
| Popis: | Objective: To evaluate regional calf muscle microcirculation in people with diabetes mellitus (DM) with and without foot ulcers, compared to healthy control people without DM, using contrast-free magnetic resonance imaging methods. Methods: Three groups of subjects were recruited: non-DM controls, DM, and DM with foot ulcers (DM + ulcer), all with ankle brachial index (ABI) > 0.9. Skeletal muscle blood flow (SMBF) and oxygen extraction fraction (SMOEF) in calf muscle were measured at rest and during a 5-min isometric ankle plantarflexion exercise. Subjects completed the Yale physical activity survey. Results: The exercise SMBF (ml/min/100 g) of the medial gastrocnemius muscle were progressively impaired: 63.7 ± 18.9 for controls, 42.9 ± 6.7 for DM, and 36.2 ± 6.2 for DM + ulcer, p Conclusions: Contrast-free MR imaging identified progressively impaired regional microcirculation in medial gastrocnemius muscles of people with DM with and without foot ulcers. Exercise SMBF in the medial gastrocnemius muscle was the most sensitive index and was associated with HbA1c. Lower exercise SMBF in the soleus muscle was associated with lower Yale score. |
| Databáze: | OpenAIRE |
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