Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease
| Autor: | Gregor Heiduschka, Johannes Pammer, Boban M. Erovic, Dietmar Thurnher, Amir Maleki, Matthaeus Ch. Grasl, Christian Schopper, Markus Brunner, Laurenz Vormittag |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adenoma Adenoma Pleomorphic Kaplan-Meier Estimate Salivary Glands Minor Gastroenterology Disease-Free Survival Cohort Studies Mucoepidermoid carcinoma Internal medicine medicine Carcinoma Humans Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Analysis of Variance business.industry Cancer Middle Aged Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic Combined Modality Therapy Survival Analysis Surgery Treatment Outcome Carcinoma ex pleomorphic adenoma Otorhinolaryngology Chemotherapy Adjuvant Salivary gland cancer Multivariate Analysis Adenocarcinoma Carcinoma Mucoepidermoid Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Head & Neck. 32:1167-1172 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.21312 |
| Popis: | Our aim in this study was to identify prognostic factors and the optimal therapeutic management in patients with minor salivary gland carcinomas.Overall and disease-free survival and overall survival after recurrence in patients with adenoidcystic carcinoma (n = 25), mucoepidermoid carcinoma (n = 8), adenocarcinoma (n = 5), carcinoma ex pleomorphic adenoma (n = 4), and others (n = 5) were correlated to clinical data.Overall survival correlated to treatment modality (p = .039) and T classification (p = .003), whereas prolonged disease-free interval correlated to treatment (p.001) and T classification (p = .009). Overall survival after recurrence correlated to treatment of recurrence (p = .006) and initial T classification (p = .02). Multivariate analysis showed that overall survival after recurrence correlated to treatment of recurrence (p = .019) and initial T classification (p = 0.019). T classification was a prognostic factor for overall survival (p = .002) and disease-free interval (p = .002).The initial tumor classification is a clinical predictor for patients' overall and disease-free survival and overall survival after recurrence. Multimodal treatment significantly improves patients' overall survival. |
| Databáze: | OpenAIRE |
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