Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition
| Autor: | Tracy L. Bale, Deborah R. Kim, Stephanie Scalice, Mary D. Sammel, C. Neill Epperson, Ellen W. Freeman, Katharine Freeman, Sarah E. Conlin |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Child abuse Domestic Violence medicine.medical_specialty Adolescent Family Conflict Cohort Studies Life Change Events 03 medical and health sciences 0302 clinical medicine Child of Impaired Parents Risk Factors Surveys and Questionnaires mental disorders medicine Humans Child Abuse Child Psychiatry First episode Depressive Disorder Major 030219 obstetrics & reproductive medicine business.industry Child Abuse Sexual Odds ratio Middle Aged medicine.disease Menopause Psychiatry and Mental health Cross-Sectional Studies Child Preschool Cohort Menarche Major depressive disorder Female business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | The Journal of Clinical Psychiatry. 78:e298-e307 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.16m10662 |
| Popis: | Objective Stress exposures may have a differential impact on risk and resilience for depression depending on their timing across development. We sought to determine whether adverse childhood experiences (ACEs) and their onset with respect to puberty contribute to the increased risk observed in first-episode major depressive disorder (MDD) during the menopause transition. Methods Participants were from the Penn Ovarian Aging Study cohort, which is composed of women from Philadelphia County, Pennsylvania, who underwent behavioral, cognitive, and endocrine evaluations approximately yearly from 1996 to 2012 and completed the Adverse Childhood Experiences Questionnaire at study end point (n = 243). ACEs that first occurred 2 or more years before menarche were considered prepubertal. Incident menopause MDD was defined as first observed onset of the disorder in the perimenopause to postmenopause transition using the Structured Clinical Interview for DSM-III-R and the Primary Care Evaluation of Mental Disorders. Results Incident menopause MDD occurred in 48% of the 100 women who reported lifetime MDD. Women reporting ≥ 2 total ACEs were at significantly greater risk for lifetime MDD (adjusted odds ratio [aOR] = 2.05, P = .034) and incident menopause MDD (aOR = 2.58, P = .03) compared to those reporting 0 ACEs; women with ≥ 2 postpubertal ACEs were 2.3 times more likely to experience incidence menopause MDD (P = .024) after controlling for race, smoking, body mass index, and employment. Experiencing only 1 ACE in the prepubertal window, regardless of additional ACEs in postpuberty, was associated with reduced risk for lifetime and incident menopause MDD. Conclusions Timing and number of adverse experiences with respect to puberty differentially impacted risk and resilience for MDD across the female life span and during the menopause transition in this community cohort. |
| Databáze: | OpenAIRE |
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