Circulating dendritic cell precursors in chronic kidney disease: a cross-sectional study

Autor: Paul, Katharina, Kretzschmar, Daniel, Yilmaz, Atilla, Bärthlein, Barbara, Titze, Stephanie, Wolf, Gunter, Busch, Martin, GCKD-Study Investigators, Eitner, Frank, Schlieper, Georg Rainer, Findeisen, K., Arweiler, E., Ernst, S., Unger, M., Flöge, Jürgen, Schaeffner, E., Baid-Agrawal, S., Petzold, K., Schindler, R., Hilgers, K. F., Hübner, S., Avendano, S., Becker-Grosspietsch, D., Köttgen, A., Schultheiss, U., Meder, S., Mitsch, E., Walz, G., Lorenzen, J., Kielstein, J. T., Otto, P., Haller, H., Sommerer, C., Föllinger, C., Löschner, T., Zeier, M., Busch, M., Paul, K., Dittrich, L., Wolf, G., Sitter, T., Hilge, R., Blank, C., Krane, V., Schmiedeke, D., Toncar, S., Cavitt, D., Wanner, C., Franz, S., Eckardt, K. U., Titze, S., Hauck, N., Seuchter, S. A., Hausknecht, B., Rittmeier, M., Weigel, A., Prokosch, H. U., Bärthlein, B., Haberländer, K., Beck, A., Ganslandt, T., Stefan, S., Knispel, S., Dressel, T., Gefeller, O., Schmid, M., Malzer, M., Reis, A., Ekici, A. B., Kronenberg, F., Kollerits, B., Weißensteiner, H., Forer, L., Schönherr, S., Oefner, P., Gronwald, W.
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Nephrology
Male
Myeloid
610 Medizin
Disease
Comorbidity
Coronary Artery Disease
Gastroenterology
Coronary artery disease
Medizinische Fakultät
Risk Factors
Germany
Dendritic Cells/pathology
Prevalence
570 Biowissenschaften
Biologie
Hematopoietic Stem Cells/pathology
Aged
80 and over
ddc:610
Middle Aged
Coronary Artery Disease/pathology
Renal Insufficiency
Chronic/pathology
Causality
medicine.anatomical_structure
Female
ddc:570
medicine.symptom
Research Article
Adult
medicine.medical_specialty
ddc:500
Germany/epidemiology
Inflammation
Young Adult
Immune system
Internal medicine
medicine
Humans
Renal Insufficiency
Chronic
Aged
business.industry
Dendritic Cells
medicine.disease
Hematopoietic Stem Cells
Blood Cell Count
Blood Cell Count/statistics & numerical data
Cross-Sectional Studies
Immunology
500 Naturwissenschaften
business
Kidney disease
Zdroj: BMC Nephrology
BMC nephrology 14, 274 (2013). doi:10.1186/1471-2369-14-274
ISSN: 1471-2369
DOI: 10.1186/1471-2369-14-274
Popis: BACKGROUND: Dendritic cells (DC) are professional antigen-presenting cells in the immune system. They patrol the blood as circulating dendritic cell precursors (DCP). Decreased blood DCP count has been shown to be related to atherosclerotic plaque burden. Since chronic kidney disease (CKD) is associated with chronic inflammation and increased cardiovascular risk, the aim of our study was to investigate a potential effect of CKD on circulating DCP numbers especially in patients with a history of cardiovascular disease. METHODS: The number of circulating myeloid (mDCP), plasmacytoid (pDCP), and total DCP (tDCP) was analysed by flow cytometry in 245 patients with CKD stage 3 (with and without known cardiovascular events) and 85 coronary healthy controls. In addition, data were compared with a historical group of 130 patients with known coronary artery disease (CAD). RESULTS: Compared to controls, patients with CKD 3 revealed a significant decrease in circulating mDCP (-29%), pDCP (-43%), and tDCP (-38%) (P < 0.001, respectively). Compared with CAD-patients, the decrease in circulating DCP in CKD was comparable or even more pronounced indicating a potential role for DCP in cardiovascular risk potentiation due to CKD. CONCLUSIONS: Based on previous findings in CAD, the marked decrease of DCP in CKD implicates a potential role for DCP as a mediator of cardiovascular disease. Whether DCP in CKD may act as new cardiovascular biomarkers needs to be established in future prospective trials.
authors on behalf of the GCKD-Study Investigators
Databáze: OpenAIRE
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