Polymorphisms in ABC transporter genes and concentrations of mercury in newborns - Evidence from two Mediterranean birth cohorts

Autor: Mariona Bustamante, Alexia Prasouli, Elisa Franforte, Mario Murcia, Eleni Antonopoulou, Jordi Sunyer, Karin Engström, Janja Snoj Tratnik, Ioanna Antoniadou, Ayman Alhamdow, Ferran Ballester, Αikaterini Sofianou-Katsoulis, Datja Mazej, Sheena Nakou, Sabrina Llop, Karin Broberg, Fabio Barbone, Marisa Rebagliato, Federica Edith Pisa, Milena Horvat
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Fetus -- Creixement
Maternal Health
Embaràs
Environmental Health and Occupational Health
lcsh:Medicine
Physiology
ATP-binding cassette transporter
Sang
Toxicology
Heavy Metals
Biochemistry
Cohort Studies
chemistry.chemical_compound
Gene Frequency
Pregnancy
Surveys and Questionnaires
Genotype
Medicine and Health Sciences
Toxins
lcsh:Science
Methylmercury
Genetics
Multidisciplinary
Greece
Obstetrics and Gynecology
Fetal Blood
Multidrug Resistance-Associated Protein 2
3. Good health
Chemistry
Italy
Maternal Exposure
Research Design
Cord blood
Blood Chemistry
Physical Sciences
Population study
Female
Epigenetics
Research Article
Adult
Neurotoxicology
Pollutants
Clinical Research Design
Toxic Agents
Single-nucleotide polymorphism
Biology
Research and Analysis Methods
Young Adult
Fish Products
medicine
Humans
Environmental Chemistry
Allele frequency
Nutrition
Evolutionary Biology
Polymorphism
Genetic
Population Biology
lcsh:R
Infant
Newborn
Biology and Life Sciences
Computational Biology
Human Genetics
Mercury
medicine.disease
chemistry
Spain
Genetic Polymorphism
Women's Health
ATP-Binding Cassette Transporters
lcsh:Q
Population Genetics
Zdroj: PLoS One
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositori Universitat Jaume I
Universitat Jaume I
PLoS ONE, Vol 9, Iss 5, p e97172 (2014)
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE
r-FISABIO. Repositorio Institucional de Producción Científica
PLoS ONE; 9(5), no e97172 (2014)
ISSN: 1932-6203
Popis: Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding cassette (ABC) transporters actively transport various xenobiotics across biological membranes. Objective: To investigate the role of ABC polymorphisms as modifiers of prenatal exposure to MeHg. Methods: The study population consisted of participants (n = 1651) in two birth cohorts, one in Italy and Greece (PHIME) and the other in Spain (INMA). Women were recruited during pregnancy in Italy and Spain, and during the perinatal period in Greece. Total mercury concentrations were measured in cord blood samples by atomic absorption spectrometry. Maternal fish intake during pregnancy was determined from questionnaires. Polymorphisms (n = 5) in the ABC genes ABCA1, ABCB1, ABCC1 and ABCC2 were analysed in both cohorts. Results: ABCB1 rs2032582, ABCC1 rs11075290, and ABCC2 rs2273697 modified the associations between maternal fish intake and cord blood mercury concentrations. The overall interaction coefficient between rs2032582 and log2-transformed fish intake was negative for carriers of GT (β = −0.29, 95%CI −0.47, −0.12) and TT (β = −0.49, 95%CI −0.71, −0.26) versus GG, meaning that for a doubling in fish intake of the mothers, children with the rs2032582 GG genotype accumulated 35% more mercury than children with TT. For rs11075290, the interaction coefficient was negative for carriers of TC (β = −0.12, 95%CI −0.33, 0.09), and TT (β = −0.28, 95%CI −0.51, −0.06) versus CC. For rs2273697, the interaction coefficient was positive when combining GA+AA (β = 0.16, 95%CI 0.01, 0.32) versus GG. Conclusion: The ABC transporters appear to play a role in accumulation of MeHg during early development. This study was funded by The European Union 6th and 7th framework projects PHIME NEWGENERIS, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Research Council FORMAS. The INMA study was funded by grants from the Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0031), UE (FP7-ENV-2011 DENAMIC cod 282957 and HEALTH.2010.2.4.5-1), Spanish Ministry of Health (FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/02591, 04/1436, 04/2018, 09/02311, 06/0867, 08/1151, 11/02038, CP11/00178), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Fundació La marató de TV3 (090430) and European Union Sixth Framework Project (NEWGENERIS FP6-2003-Food-3-A-016320). National funding for the PHIME project in Slovenia was provided by the programme ARRS P1-0143.
Databáze: OpenAIRE
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