Bone quality factor analysis: A new noninvasive technique for the measurement of bone density and bone strength
| Autor: | Roberto Pacifici, Andrew D. Dimarogonas, R B Kimble, S. Hasan Abbasi-Jahromi, Alicia Matayoshi |
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| Rok vydání: | 2009 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Bone disease Bone density Pathologic fracture Endocrinology Diabetes and Metabolism Coefficient of variation Osteoporosis Bone and Bones Rats Sprague-Dawley Fractures Bone Mice Bone Density Risk Factors Methods medicine Animals Orthopedics and Sports Medicine Femur Bone mineral business.industry medicine.disease Biomechanical Phenomena Rats Surgery Densitometry business Nuclear medicine |
| Zdroj: | Journal of Bone and Mineral Research. 11:594-599 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.5650110507 |
| Popis: | The sensitivity of bone mineral density (BMD) as a predictor of fracture risk is limited by the fact that this index does not take into account the geometrical and material characteristics of bone. In contrast, both BMD and bone architecture influence the quality factor (QF), the fraction of the inverse of the energy lost in one cycle of deformation. In this study we have compared the sensitivity of a QF analyzer and dual-energy X-ray absorptiometry (DXA) in detecting the changes induced by ovariectomy (OVX) on the QF, impact strength, and BMD of the femur of mature rats. QF and BMD were measured noninvasively before and 4 weeks after OVX or sham operation using a QF analyzer developed in our laboratory and a Hologic QDR 2000 bone densitometry, respectively. Impact strength was measured in excised femurs at the end of the study. The in vivo short-term precision (coefficient of variation) of the QF analyzer was 1.9%. BMD and QF measurements were highly correlated (r = 0.80,p |
| Databáze: | OpenAIRE |
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