Hyperlactatemia After Intracranial Tumor Surgery Does Not Affect 6-Month Survival: A Retrospective Case Series
| Autor: | Peter P de Smalen, Tom J. van Ark, Markus Klimek, Arnaud J P E Vincent, Robert Jan Stolker |
|---|---|
| Přispěvatelé: | Anesthesiology, Neurosurgery |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 6-month survival medicine.medical_specialty Clinical Investigations hyperlactemia dexamethasone Neurosurgical Procedures Cohort Studies 03 medical and health sciences Postoperative Complications 0302 clinical medicine 030202 anesthesiology Interquartile range medicine Humans Hyperlactatemia neurosurgery Dexamethasone Survival analysis Aged Retrospective Studies Acidosis Brain Neoplasms business.industry Retrospective cohort study Hydrogen-Ion Concentration Length of Stay Middle Aged Survival Analysis Surgery lactic acidosis Treatment Outcome Anesthesiology and Pain Medicine ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Neurology (clinical) Neurosurgery medicine.symptom business 030217 neurology & neurosurgery Cohort study medicine.drug |
| Zdroj: | Journal of Neurosurgical Anesthesiology, 32(1), 48-56. Lippincott Williams & Wilkins Journal of Neurosurgical Anesthesiology |
| ISSN: | 0898-4921 |
| DOI: | 10.1097/ana.0000000000000594 |
| Popis: | Supplemental Digital Content is available in the text. Background: Patients undergoing neurosurgery frequently exhibit hyperlactatemia. The aim of this study was to identify factors associated with hyperlactatemia and assess how hyperlactatemia impacts survival and hospital length of stay after intracranial tumor surgery. Materials and Methods: This retrospective cohort study included 496 adult patients that underwent surgery between January 1, 2014 and December 31, 2015. We evaluated patient characteristics, surgery characteristics, pH, lactate, and blood glucose from blood samples collected on admission to the high-dependency unit and the morning after surgery, and 6-month outcome data. Results: Hyperlactatemia (>2.0 mmol/L) occurred in >50% of patients, but only 7.7% had acidosis. Postoperative hyperlactatemia was not correlated with 6-month survival (P=0.987), but was correlated with (median [interquartile range]) longer hospital stays (6 [4 to 8.5] d vs. 5 [4 to 8] d; P=0.006), longer surgery duration (4:53 [4:01 to 6:18] h:min vs. 4:28 [3:33 to 5:53] h:min; P=0.001), higher dexamethasone dose (16 [16 to 35] mg vs. 16 [16 to 20] mg; P |
| Databáze: | OpenAIRE |
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